Ernst F D
Z Gesamte Inn Med. 1985 May 1;40(9):249-56.
The measurement of the partial pressure of oxygen in the tissue is a method increasingly used in experiment and clinic, the technical prerequisites for this having been created by means of the development of polarographic measuring techniques (surface or scarifier-electrodes). The pO2-measurement of the tissue renders possible independent conclusions to the relations of microcirculation of the organs examined and to the effectiveness of the blood supply of the tissue as well as its homogeneity and nutritive achievement for the cellular metabolism. On the basis of the intravital microscopic findings in connection with perivascular pO2-measurement the pathophysiological peculiarities of this measuring method are discussed. The physiologically involved temporary and spatial inhomogeneities of the peripheral blood supply limit, however, the generalization of locally (approximately 200-300 microns3 measuring area) established oxygen values for diagnostics and therapy control. For the measurement an intact microcirculation and the simultaneous registration in several measuring places is necessary. Then the following informations may be obtained, e.g.: control of the exact dosage of an inspiratory O2-supply--control of the volume balance--control of the haemodynamic effect of drugs on the microcirculation.
组织中氧分压的测量是一种在实验和临床中越来越常用的方法，极谱测量技术（表面电极或划痕电极）的发展为此创造了技术前提。组织的pO₂测量使得能够独立得出有关所检查器官微循环关系、组织血液供应有效性及其均匀性以及对细胞代谢的营养作用的结论。基于与血管周围pO₂测量相关的活体显微镜检查结果，讨论了这种测量方法的病理生理特性。然而，外周血供应在生理上涉及的暂时和空间不均匀性限制了将局部（约200 - 300立方微米测量区域）确定的氧值用于诊断和治疗控制的推广。为了进行测量，完整的微循环以及在多个测量点的同步记录是必要的。然后可以获得以下信息，例如：控制吸入氧气供应的精确剂量——控制容量平衡——控制药物对微循环的血液动力学效应。
