von Ardenne M
Z Alternsforsch. 1985 Nov-Dec;40(6):357-68.
Different effects of a bad oxygen state of the organism on several organs an tissues as well as observed differences in their response to a lasting restoration of a good oxygen state by the Oxygen Multistep Therapy (O2MT) initiated the search for the (common) cause of these differences. From the view of our O2MT research, the organ- and tissue-specific different levels of the switching threshold of the bioenergetically controlled switching mechanism of blood microcirculation were suspected to be decisive. Observations discussed here revealed that this switching threshold is controlled by the local venous pO2 values and the capillary blood-flow. When the microcirculation is initially little changed (starting situation), the pathogenic lowering of microcirculation in different organs and tissues is mainly dependent on the venous oxygen partial pressure. From a scale containing venous pO2 values of different organs and tissues for two ages on can obtain the following order of succession with increasing pO2-ven: heart, lower extremities, brain (circulatory disorders), upper extremities, lungs, liver, stomach and bowel, skin, kidneys, spleen. This order agrees well with clinical findings on the frequency of diseases and disorders in different organs in relation to the increasingly insufficient oxygen state (progressing age). On the other hand, this sequence is also in good correlation with clinical observations, which are given here and show the abolition of pathogenic disturbances in different organs and tissues after "step-up" of microcirculation by means procedures of the O2MT. Finally, the abrogation of peripheral circulatory disorders of the lower extremities is discussed as a paradigm. The specific feature of this disease is to additionally weaken the oxygen state of the organism by the constraint in ability to move.
机体不良氧状态对多个器官和组织的不同影响，以及观察到它们对通过氧多步疗法（O2MT）持久恢复良好氧状态的反应差异，引发了对这些差异（共同）原因的探索。从我们的O2MT研究角度来看，怀疑生物能量控制的血液微循环切换机制的器官和组织特异性不同切换阈值水平起决定性作用。此处讨论的观察结果表明，该切换阈值由局部静脉血氧分压值和毛细血管血流量控制。当微循环最初变化不大（起始状态）时，不同器官和组织中微循环的病理性降低主要取决于静脉氧分压。从包含两个年龄段不同器官和组织静脉血氧分压值的量表上，可以得到随着静脉血氧分压升高的以下顺序：心脏、下肢、脑（循环障碍）、上肢、肺、肝、胃和肠、皮肤、肾、脾。这个顺序与不同器官中疾病和障碍发生频率与氧状态日益不足（年龄增长）相关的临床发现非常吻合。另一方面，这个顺序也与临床观察结果高度相关，这里给出的临床观察结果显示，通过O2MT程序使微循环“升压”后，不同器官和组织中的病理性紊乱得以消除。最后，将下肢外周循环障碍的消除作为一个范例进行讨论。这种疾病的具体特征是通过运动能力受限进一步削弱机体的氧状态。
