Subedi Roshan, Misbah Afrah, Najada Adnan Al, Ocon Anthony James
Division of Rheumatology, MedStar Washington Hospital Center, Washington, DC, USA.
Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
J Rheum Dis. 2025 Apr 1;32(2):130-135. doi: 10.4078/jrd.2024.0110. Epub 2024 Dec 4.
Serum 14-3-3eta are novel biomarkers of rheumatoid arthritis (RA). It is not clear whether 14-3-3eta may be present in other forms of inflammatory arthritis (IA). We evaluated the presence of 14-3-3eta as a diagnostic biomarker in the evaluation IA.
A retrospective cohort study of adult patients who were evaluated for IA by a rheumatologist with a result for the lab test of 14-3-3eta was conducted.
Of 280 included patients, 30% were diagnosed with RA, 11% with psoriatic arthritis (PsA), and 59% with another condition. Twenty-four (9%) patients had positive results for 14-3-3eta. Fifty-two percent of positive patients were diagnosed with RA, with 48% having another diagnosis including axial spondyloarthritis, gout, Sjögren's, undifferentiated IA, diabetic cheiroarthropathy, prostate cancer with bone metastasis, osteoarthritis, unspecified arthralgia. No patients with PsA had a positive value. RA patients had a higher value for 14-3-3eta compared to non-RA (5.44 [1.569.31] vs. 0.69 [0.400.98] ng/mL, p=0.03, square brackets are 95% confidence interval values). The mean value for the 14-3-3eta in seropositive RA trended higher than seronegative (8.0 [2.313.7] vs. 1.4 [0.42.4] ng/mL, p=0.06). In the RA cohort, elevated 14-3-3eta was associated with elevated erythrocyte sedimentation rate (odd ratio=6.62 [1.24~47.09], p<0.04), but not other variables.
14-3-3eta may aid as a diagnostic biomarker of RA. However, it is not specific for RA, especially at low positive levels, and may be positive in other forms of IA. Ideal cutoff values need to be established for RA and non-RA conditions. It was not found in PsA.
血清14-3-3eta是类风湿关节炎（RA）的新型生物标志物。目前尚不清楚14-3-3eta是否可能以其他形式存在于炎性关节炎（IA）中。我们评估了14-3-3eta作为IA诊断生物标志物的存在情况。
对成年患者进行了一项回顾性队列研究，这些患者由风湿病学家评估IA，并进行了14-3-3eta的实验室检测。
在纳入的280例患者中，30%被诊断为RA，11%为银屑病关节炎（PsA），59%为其他病症。24例（9%）患者14-3-3eta检测结果为阳性。52%的阳性患者被诊断为RA，48%有其他诊断，包括轴向脊柱关节炎、痛风、干燥综合征、未分化IA、糖尿病性手关节病、前列腺癌伴骨转移、骨关节炎、未明确的关节痛。没有PsA患者检测值为阳性。与非RA患者相比，RA患者的14-3-3eta值更高（5.44[1.569.31]对0.69[0.400.98]ng/mL，p = 0.03，方括号为95%置信区间值）。血清阳性RA患者的14-3-3eta平均值高于血清阴性患者（8.0[2.313.7]对1.4[0.42.4]ng/mL，p = 0.06）。在RA队列中，14-3-3eta升高与红细胞沉降率升高相关（比值比 = 6.62[1.24~47.09]，p < 0.04），但与其他变量无关。
14-3-3eta可能有助于作为RA的诊断生物标志物。然而，它对RA并不特异，尤其是在低阳性水平时，可能在其他形式的IA中呈阳性。需要为RA和非RA病症确定理想的临界值。在PsA中未发现。
