不良生活习惯与皮肤黑色素瘤风险之间的关联：一项孟德尔随机化研究。
Association Between Poor Lifestyle Habits and Cutaneous Melanoma Risk: A Mendelian Randomization Study.
作者信息
Liu Xiaohui, Luan Wenkang, Fan Shujun, Liu Tengfei
机构信息
Department of Burn and Plastic Surgery, Shengli Oilfield Central Hospital, Dongying, Shandong, People's Republic of China.
Department of Auricular Reconstruction, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
出版信息
Clin Cosmet Investig Dermatol. 2025 Mar 21;18:687-697. doi: 10.2147/CCID.S506547. eCollection 2025.
BACKGROUND
There is still no consensus on the risk factors of cutaneous melanoma, and the causal relationship between poor lifestyle habits (including undersleeping, smoking, alcohol consumption and sedentary behaviour) and cutaneous melanoma remains uncertain.
METHODS
We investigated the causal effect of poor lifestyle habits on cutaneous melanoma through the Two-sample Mendelian randomization (MR). MR analysis was performed by using the genome-wide association studies (GWAS) statistics. Single-nucleotide polymorphisms (SNPs) robustly associated with undersleeping, smoking, alcohol consumption and sedentary behaviour were used as instrumental variables, we performed five MR approaches, including inverse variance weighted (IVW), weighted median, simple mode, MR-Egger and weighted mode.
RESULTS
The causal relationship between undersleeping and cutaneous melanoma was discovered in IVW (OR = 1.018, 95% CI = 1.002-1.033, P = 0.025). However, the causal association between smoking, alcohol consumption, sedentary behaviour and cutaneous melanoma have not been found in all MR approaches.
CONCLUSION
The MR analysis indicated that undersleeping is causally associated with the risk of cutaneous melanoma.
背景
皮肤黑色素瘤的危险因素仍未达成共识，不良生活习惯（包括睡眠不足、吸烟、饮酒和久坐行为）与皮肤黑色素瘤之间的因果关系仍不确定。
方法
我们通过两样本孟德尔随机化（MR）研究了不良生活习惯对皮肤黑色素瘤的因果效应。MR分析使用全基因组关联研究（GWAS）统计数据进行。与睡眠不足、吸烟、饮酒和久坐行为密切相关的单核苷酸多态性（SNP）用作工具变量，我们进行了五种MR方法，包括逆方差加权（IVW）、加权中位数、简单模式、MR-Egger和加权模式。
结果
在IVW中发现睡眠不足与皮肤黑色素瘤之间存在因果关系（OR = 1.018，95%CI = 1.002 - 1.033，P = 0.025）。然而，在所有MR方法中均未发现吸烟、饮酒、久坐行为与皮肤黑色素瘤之间存在因果关联。
结论
MR分析表明睡眠不足与皮肤黑色素瘤风险存在因果关系。
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