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微血管病性溶血性贫血作为嗜铬细胞瘤继发的副肿瘤综合征:一例罕见病例报告

Microangiopathic Hemolytic Anemia as paraneoplastic syndrome secondary to Pheochromocytoma: a rare case report.

作者信息

Heih Omar Q, Manasra Mahmoud R, Salah Ziad F, Hroub Monther M, Arafat Hassan, Abu Aqeel Bashir I, Hammouri Ahmad G

机构信息

Faculty of Medicine, Palestine Polytechnic University, Wadi Hariya Campus, Hebron, Palestine.

Internal Medicine Department, Augusta Victoria Hospital, Mount of Olives, Jerusalem, Palestine.

出版信息

Oxf Med Case Reports. 2025 Mar 25;2025(3):omaf034. doi: 10.1093/omcr/omaf034. eCollection 2025 Mar.

Abstract

Pheochromocytoma is a rare adrenal tumor that secretes catecholamines. Microangiopathic hemolytic anemia, a kind of hemolytic anemia in which erythrocytes are destroyed in microscopic blood capillaries, resulting in fragmentation and hemolysis. This condition is an uncommon but significant consequence observed most commonly in malignant pheochromocytoma. In this case report, we present a 21-year-old single female with a strong family history of endocrine malignancy. She was referred to our hospital for chemotherapy due to a diagnosis of malignant pheochromocytoma, which had metastasized to the urinary bladder, bone, and lung. Additionally, she developed microangiopathic hemolytic anemia as a paraneoplastic syndrome.

摘要

嗜铬细胞瘤是一种罕见的分泌儿茶酚胺的肾上腺肿瘤。微血管病性溶血性贫血是一种溶血性贫血,其中红细胞在微小血管中被破坏,导致破碎和溶血。这种情况是一种不常见但重要的后果,最常见于恶性嗜铬细胞瘤。在本病例报告中,我们介绍了一名21岁的单身女性,她有内分泌恶性肿瘤的家族史。她因诊断为恶性嗜铬细胞瘤并已转移至膀胱、骨骼和肺部而被转诊至我院进行化疗。此外,她还出现了微血管病性溶血性贫血作为副肿瘤综合征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58d9/11934550/569af8198d38/omaf034f1.jpg

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