Saeed Nermin K, Almusawi Safiya K, Albalooshi Noor A, Al-Beltagi Mohammed
Medical Microbiology Section, Department of Pathology, Salmaniya Medical Complex, Governmental Hospitals, Manama 12, Bahrain.
Medical Microbiology Section, Department of Pathology, Royal College of Surgeons in Ireland-Medical University of Bahrain, Busaiteen 15503, Muharraq, Bahrain.
World J Virol. 2025 Mar 25;14(1):100501. doi: 10.5501/wjv.v14.i1.100501.
Antibiotic resistance is a growing global health threat, and understanding local trends in bacterial isolates and their susceptibility patterns is crucial for effective infection control and antimicrobial stewardship. The coronavirus disease 2019 (COVID-19) pandemic has introduced additional complexities, potentially influencing these patterns.
To analyze trends in bacterial isolates and their antibiotic susceptibility patterns at Salmaniya Medical Complex from 2018 to 2023, with a specific focus on the impact of the COVID-19 pandemic on these trends.
A retrospective analysis of microbiological data was conducted, covering the period from 2018 to 2023. The study included key bacterial pathogens such as (), , , , and , among others. The antibiotic susceptibility profiles of these isolates were assessed using standard laboratory methods. To contextualize the findings, the findings were compared with similar studies from other regions, including China, India, Romania, Saudi Arabia, the United Arab Emirates, Malaysia, and United States.
The study revealed fluctuating trends in the prevalence of bacterial isolates, with notable changes during the COVID-19 pandemic. For example, a significant increase in the prevalence of was observed during the pandemic years, while the prevalence of showed a more variable pattern. Antibiotic resistance rates varied among the different pathogens, with a concerning rise in resistance to commonly used antibiotics, particularly among and . Additionally, the study identified an alarming increase in the prevalence of multidrug-resistant (MDR) strains, especially within and isolates. The impact of the COVID-19 pandemic on these trends was evident, with shifts in the frequency, resistance patterns, and the emergence of MDR bacteria among several key pathogens.
This study highlights the dynamic nature of bacterial isolates and their antibiotic susceptibility patterns at Salmaniya Medical Complex, particularly in the context of the COVID-19 pandemic. The findings underscore the need for continuous monitoring and effective anti-microbial stewardship programs to combat the evolving threat of antibiotic resistance. Further research and policy initiatives are required to address the identified challenges and improve patient outcomes in the face of these ongoing challenges.
抗生素耐药性是全球日益严重的健康威胁，了解细菌分离株的当地趋势及其药敏模式对于有效的感染控制和抗菌药物管理至关重要。2019年冠状病毒病（COVID-19）大流行带来了更多复杂性，可能会影响这些模式。
分析2018年至2023年萨勒曼尼亚医疗中心细菌分离株及其抗生素药敏模式的趋势，特别关注COVID-19大流行对这些趋势的影响。
对2018年至2023年期间的微生物学数据进行回顾性分析。该研究包括关键细菌病原体，如（）、、、、等。使用标准实验室方法评估这些分离株的抗生素药敏谱。为了将研究结果置于背景中，将这些结果与来自其他地区的类似研究进行了比较，这些地区包括中国、印度、罗马尼亚、沙特阿拉伯、阿联酋、马来西亚和美国。
该研究揭示了细菌分离株流行率的波动趋势，在COVID-19大流行期间有显著变化。例如，在大流行年份观察到的流行率显著增加，而的流行率则呈现出更多变的模式。不同病原体的抗生素耐药率各不相同，对常用抗生素的耐药性令人担忧地上升，尤其是在和中。此外，该研究发现多重耐药（MDR）菌株的流行率惊人地增加，特别是在和分离株中。COVID-19大流行对这些趋势的影响很明显，几个关键病原体的频率、耐药模式发生了变化，并且出现了MDR细菌。
本研究突出了萨勒曼尼亚医疗中心细菌分离株及其抗生素药敏模式的动态性质,特别是在COVID-19大流行的背景下。研究结果强调了持续监测和有效的抗菌药物管理计划以应对不断演变的抗生素耐药性威胁的必要性。面对这些持续的挑战，需要进一步的研究和政策举措来应对已发现的挑战并改善患者预后。
