Mao Tingting, Zhai Huijuan, Duan Guangcai, Yang Haiyan
Department of Epidemiology, College of Public Health of Zhengzhou University , Zhengzhou, Henan , China.
Pol J Microbiol. 2019;68(2):225-232. doi: 10.33073/pjm-2019-024.
Drug-resistant bacteria has been a threat to public life and property. We described the trends and changes in antibiotic resistance of important pathogens in a general hospital in Zhengzhou, China from 2011 to 2016, to control antimicrobial-resistant bacteria in hospital and provide support to clinicians and decision-making departments. Five dominant bacteria were enrolled based on the data from the general hospital during 6 years. The results of antimicrobial susceptibility testing were interpreted according to Clinical and Laboratory Standards Institute (CLSI). From 2011 to 2016, a total of 19,260 strains of bacteria were isolated, of which and accounted for 51.98%. The resistance rate of and to carbapenem was less than 15%, but resistance of to carbapenems increased with time and resistance of to meropenem increased. The rate of extended-spectrum beta-lactamase (ESBL) production among and was decreasing. For most antibiotics, the resistance rate of ESBL-positive isolates was higher than that of ESBL-negative isolates, excluding carbapenems and cefoxitin. For , the rate of methicillin-resistant (MRSA) was stable. Resistance of to mostly antibiotics decreased with time. Besides polymyxin B, and showed high resistance to other antibiotics. For , the resistance rate to mostly antibiotics was increasing. The bacteria showed high levels of resistance and multiple drug resistance. Continuous surveillance and optimizing the use of antibiotics are essential. Drug-resistant bacteria has been a threat to public life and property. We described the trends and changes in antibiotic resistance of important pathogens in a general hospital in Zhengzhou, China from 2011 to 2016, to control antimicrobial-resistant bacteria in hospital and provide support to clinicians and decision-making departments. Five dominant bacteria were enrolled based on the data from the general hospital during 6 years. The results of antimicrobial susceptibility testing were interpreted according to Clinical and Laboratory Standards Institute (CLSI). From 2011 to 2016, a total of 19,260 strains of bacteria were isolated, of which and accounted for 51.98%. The resistance rate of and to carbapenem was less than 15%, but resistance of to carbapenems increased with time and resistance of to meropenem increased. The rate of extended-spectrum beta-lactamase (ESBL) production among and was decreasing. For most antibiotics, the resistance rate of ESBL-positive isolates was higher than that of ESBL-negative isolates, excluding carbapenems and cefoxitin. For , the rate of methicillin-resistant (MRSA) was stable. Resistance of to mostly antibiotics decreased with time. Besides polymyxin B, and showed high resistance to other antibiotics. For , the resistance rate to mostly antibiotics was increasing. The bacteria showed high levels of resistance and multiple drug resistance. Continuous surveillance and optimizing the use of antibiotics are essential.
耐药菌一直威胁着公众的生命和财产安全。我们描述了2011年至2016年中国郑州一家综合医院重要病原菌的抗生素耐药性趋势和变化，以控制医院内的抗菌耐药菌，并为临床医生和决策部门提供支持。根据该综合医院6年的数据纳入了5种主要细菌。抗菌药物敏感性试验结果依据临床和实验室标准协会（CLSI）进行解读。2011年至2016年，共分离出19260株细菌，其中[具体细菌名称1]和[具体细菌名称2]占51.98%。[具体细菌名称1]和[具体细菌名称2]对碳青霉烯类的耐药率低于15%，但[具体细菌名称1]对碳青霉烯类的耐药性随时间增加，[具体细菌名称2]对美罗培南的耐药性增加。[具体细菌名称1]和[具体细菌名称2]中产超广谱β-内酰胺酶（ESBL）的比例在下降。对于大多数抗生素，ESBL阳性分离株的耐药率高于ESBL阴性分离株，但碳青霉烯类和头孢西丁除外。对于[具体细菌名称3]，耐甲氧西林[具体细菌名称3]（MRSA）的比例稳定。[具体细菌名称4]对大多数抗生素的耐药性随时间下降。除多粘菌素B外，[具体细菌名称5]和[具体细菌名称6]对其他抗生素表现出高耐药性。对于[具体细菌名称7]，对大多数抗生素的耐药率在上升。这些细菌表现出高水平的耐药性和多重耐药性。持续监测和优化抗生素的使用至关重要。耐药菌一直威胁着公众的生命和财产安全。我们描述了2011年至2016年中国郑州一家综合医院重要病原菌的抗生素耐药性趋势和变化，以控制医院内的抗菌耐药菌，并为临床医生和决策部门提供支持。根据该综合医院6年的数据纳入了5种主要细菌。抗菌药物敏感性试验结果依据临床和实验室标准协会（CLSI）进行解读。从2011年至2016年，共分离出19260株细菌，其中[具体细菌名称1]和[具体细菌名称2]占51.98%。[具体细菌名称1]和[具体细菌名称2]对碳青霉烯类的耐药率低于15%，但[具体细菌名称1]对碳青霉烯类的耐药性随时间增加，[具体细菌名称2]对美罗培南的耐药性增加。[具体细菌名称1]和[具体细菌名称2]中产超广谱β-内酰胺酶（ESBL）的比例在下降。对于大多数抗生素，ESBL阳性分离株的耐药率高于ESBL阴性分离株，但碳青霉烯类和头孢西丁除外。对于[具体细菌名称3]，耐甲氧西林[具体细菌名称3]（MRSA）的比例稳定。[具体细菌名称4]对大多数抗生素的耐药性随时间下降。除多粘菌素B外，[具体细菌名称5]和[具体细菌名称6]对其他抗生素表现出高耐药性。对于[具体细菌名称7]，对大多数抗生素的耐药率在上升。这些细菌表现出高水平的耐药性和多重耐药性。持续监测和优化抗生素的使用至关重要。
