Steinmann J, Albrecht K
Zentralbl Bakteriol Mikrobiol Hyg A. 1985 Apr;259(2):284-93.
During a period of 3 weeks, 17 premature neonates 4 of them weighing less than 1000 g at birth became infected with echovirus 11 in a neonatal intensive-care unit. Beside 3 inapparent infections, severe 'septicaemic' illness was observed among 5 premature neonates combined with meningitis and apnoeic attacks. 4 neonates presented meningitis as the predominant clinical feature and 3 showed gastrointestinal symptoms without neurological involvement. 2 children experienced a febrile illness with apnoea and bradycardia. All babies recovered. Echovirus 11 could be isolated in 51 of 74 (68.9%) specimens, mainly from stool samples. The source of this epidemic outbreak has remained unclear. Virus isolations and serological examinations of antibodies of the IgM class showed that one mother and her eldest child and 3 staff members of the unit had been infected during this epidemic outbreak. The agent was identified as an antigenic variant of echovirus 11 resembling other echoviruses of this type which were isolated in other children hospitals in Bremen during this outbreak.
在3周的时间里，17名早产新生儿（其中4名出生时体重不足1000克）在新生儿重症监护病房感染了11型艾柯病毒。除3例隐性感染外，5名早产新生儿出现了严重的“败血症”疾病，伴有脑膜炎和呼吸暂停发作。4名新生儿以脑膜炎为主要临床特征，3名表现为胃肠道症状而无神经系统受累。2名儿童出现发热性疾病并伴有呼吸暂停和心动过缓。所有婴儿均康复。在74份标本中的51份（68.9%）中可分离出11型艾柯病毒，主要来自粪便样本。此次疫情爆发的源头仍不清楚。病毒分离和IgM类抗体的血清学检查表明，一名母亲及其最大的孩子以及该病房的3名工作人员在此次疫情爆发期间受到了感染。该病原体被鉴定为11型艾柯病毒的一种抗原变异体，类似于在不来梅其他儿童医院此次疫情爆发期间分离出的该类型的其他艾柯病毒。
