挪威西部霍达兰郡的多发性硬化症聚集情况。

Clustering of multiple sclerosis in the county of Hordaland, Western Norway.

作者信息

Larsen J P, Riise T, Nyland H, Kvåle G, Aarli J A

出版信息

Acta Neurol Scand. 1985 May;71(5):390-5. doi: 10.1111/j.1600-0404.1985.tb03218.x.

DOI:10.1111/j.1600-0404.1985.tb03218.x

Abstract

We studied the distribution of MS cases in the county of Hordaland, Western Norway. The total MS population comprised 426 patients. The prevalence on January 1st, 1963, and on January 1st, 1983, and the average annual incidence in the period 1963-1982 were all lower in the coastal area compared to the inland area. An increase in incidence started in the urban area and was followed some 10 years later in the rural area. The Knox method revealed no statistically significant evidence of clustering either for time/place of onset or for time/place of birth. Indications of clustering according to year of onset were, however, observed in the rural area.

摘要

我们研究了挪威西部霍达兰郡多发性硬化症（MS）病例的分布情况。MS患者总数为426例。与内陆地区相比，1963年1月1日、1983年1月1日的患病率以及1963年至1982年期间的年平均发病率在沿海地区均较低。发病率的上升始于城市地区，约10年后在农村地区出现。诺克斯方法显示，无论是发病时间/地点还是出生时间/地点，均无统计学意义上的聚集证据。然而，在农村地区观察到了根据发病年份聚集的迹象。