Lee Soung-Hoon
Department of Anatomy, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Cells. 2025 Mar 16;14(6):440. doi: 10.3390/cells14060440.
Wound-induced hair-follicle neogenesis (WIHN) is the phenomenon of regenerating new hair follicles from wounds in mammals. The WIHN involves both developmental and adult wound-healing processes. Moreover, the WIHN is regulated by a variety of factors, particularly multiple molecular signaling pathways produced in several types of cells. Here, the role of multiple signaling in different types of cells in WIHN is comprehensively described. Furthermore, the lack of dermal γδ T cells in the human scalp has hindered the clinical application of WIHN, but the development of drugs such as Wnt signaling activators is increasing the effectiveness of WIHN in humans. Overall, understanding the underlying mechanisms that regulate WIHN may help treat skin diseases, including alopecia.
伤口诱导的毛囊新生（WIHN）是哺乳动物伤口处再生新毛囊的现象。WIHN涉及发育过程和成人伤口愈合过程。此外，WIHN受多种因素调节，特别是几种类型细胞中产生的多种分子信号通路。本文全面描述了多种信号在WIHN不同类型细胞中的作用。此外，人类头皮中缺乏真皮γδ T细胞阻碍了WIHN的临床应用，但Wnt信号激活剂等药物的研发正在提高WIHN在人类中的有效性。总体而言，了解调节WIHN的潜在机制可能有助于治疗包括脱发在内的皮肤病。
