Matta Bharati, Thomas Lydia, Sharma Vinay, Barnes Betsy J
Center for Autoimmune Musculoskeletal and Hematopoietic Disease, The Feinstein Institutes for Medical Research, Manhasset, NY 11030, USA.
Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur 303002, India.
Cells. 2025 Mar 19;14(6):454. doi: 10.3390/cells14060454.
T follicular helper (Tfh) and T follicular regulatory cells (Tfr) are required for antibody production and are dysregulated in SLE. Genetic variants within or near interferon regulatory factor 5 () are associated with SLE risk. We previously reported higher plasma cells and autoantibodies in healthy -SLE homozygous risk carriers. Here, we report the dysregulation of circulating Tfh and Tfr in both SLE patients and presymptomatic -SLE homozygous risk carriers.
滤泡辅助性T细胞（Tfh）和滤泡调节性T细胞（Tfr）是抗体产生所必需的，且在系统性红斑狼疮（SLE）中失调。干扰素调节因子5（IRF5）基因内部或附近的遗传变异与SLE风险相关。我们之前报道过，健康的IRF5 - SLE纯合风险携带者体内浆细胞和自身抗体水平较高。在此，我们报告SLE患者和症状前IRF5 - SLE纯合风险携带者体内循环Tfh和Tfr均失调。
