Choroid plexus papilloma and giant cell glioblastoma induced in hamsters with bovine adenovirus type 3.

Newborn hamsters were inoculated with 0.02 ml of bovine adenovirus type 3 (BAV 3) having a titer of 10(4.5)TCID50/0.1 ml. Of 82 hamsters observed over 40 days after viral inoculation, 15 developed choroid plexus papilloma after a latency period of 41-228 days and six developed giant cell glioblastoma after a latency period of 66-214 days. Multiple foci of abnormal cell growth were also observed in the meninges and choroid plexus. Choroid plexus papilloma developed in the ventricles occupying the ventricular cavity and histologically showed a radiating arrangement of spindle-shaped cells forming perivascular pseudorosettes. Giant cell glioblastoma developed in the cerebral cortex including the meninges. The tumors were reddish in color and soft in consistency. Histologically, the tumor cells were short-spindle, oval or, pleomorphic cells with a large vesicular nucleus, and were characterized by the appearance of monster cells and hypervascularity. The short spindle-shaped cells were positive for glial fibrillary acid protein.