Greenlee J E, Narayan O, Johnson R T, Herndon R M
Lab Invest. 1977 Jun;36(6):636-41.
The oncogenicity of BK virus for the central nervous system was studied in newborn hamsters. The virus was weakly oncogenic after intracerebral inoculation. Two of 45 hamsters treated with antithymocyte serum developed tumors whereas no untreated hamsters developed tumors. Both tumors were choroid plexus papillomas by histologic and electron microscopic examination. Cells cultured from one tumor had growth characteristics of transformed cells and had intranuclear T antigen; but infectious virus could not be rescued. Cultured tumor cells were weakly oncogenic for hamsters, but theoncogenicity of these cells was enhanced when the recipient animals were treated with antithymocyte serum. The possible role of host immune response as a basis for the weak oncogenicity of BK virus is discussed.
在新生仓鼠中研究了BK病毒对中枢神经系统的致癌性。脑内接种后，该病毒具有弱致癌性。45只接受抗胸腺细胞血清治疗的仓鼠中有2只发生了肿瘤，而未治疗的仓鼠均未发生肿瘤。通过组织学和电子显微镜检查，这两个肿瘤均为脉络丛乳头状瘤。从一个肿瘤培养的细胞具有转化细胞的生长特征，并具有核内T抗原；但无法拯救出感染性病毒。培养的肿瘤细胞对仓鼠具有弱致癌性，但当受体动物接受抗胸腺细胞血清治疗时，这些细胞的致癌性会增强。讨论了宿主免疫反应作为BK病毒弱致癌性基础的可能作用。
