Negelspach David, Kennedy Kathryn E R, Huskey Alisa, Cha Jungwon, Alkozei Anna, Killgore William D S
Department of Psychiatry, University of Arizona, Tucson, AZ 85724, USA.
Clocks Sleep. 2025 Mar 13;7(1):15. doi: 10.3390/clockssleep7010015.
The regularity of sleep-wake cycles is a defining characteristic of normative sleep patterns that are typically associated with proper circadian rhythmicity. The previous literature indicates that consistent patterns of sleep and wake are associated with improved sleep quality and cognitive functioning. Conversely, sleep irregularity has been associated with reduced well-being and inefficiency in resting-state neural networks. This study investigated the relationship between specific sleep regularity measures and outcomes, including emotional affect, sleep quality, and resting-state functional connectivity. We found that variability in wake onset predicted poorer sleep quality and reduced positive affect. Furthermore, sleep regularity measures were associated with altered functional connectivity between the posterior cingulate cortex and regions involved in emotional processing. We propose that alterations in default mode network (DMN) connectivity linked to sleep irregularity reflect disruptions in emotional processing and sleep quality.
睡眠-觉醒周期的规律性是正常睡眠模式的一个决定性特征，通常与适当的昼夜节律相关。先前的文献表明，一致的睡眠和觉醒模式与改善睡眠质量和认知功能有关。相反，睡眠不规律与幸福感降低和静息状态神经网络效率低下有关。本研究调查了特定睡眠规律性指标与情绪影响、睡眠质量和静息状态功能连接等结果之间的关系。我们发现，觉醒起始时间的变异性预示着较差的睡眠质量和积极情绪的减少。此外，睡眠规律性指标与后扣带回皮质和参与情绪处理的区域之间功能连接的改变有关。我们提出，与睡眠不规律相关的默认模式网络（DMN）连接的改变反映了情绪处理和睡眠质量的中断。
