Auel Tobias, Mentrup Aaron Felix Christofer, Oldfield Lee Roy, Seidlitz Anne
Heinrich Heine University Düsseldorf, Faculty of Mathematics and Natural Sciences, Institute of Pharmaceutics and Biopharmaceutics, Universitätsstraße 1, 40225 Düsseldorf, Germany.
Heinrich Heine University Düsseldorf, Faculty of Mathematics and Natural Sciences, Institute of Pharmaceutics and Biopharmaceutics, Universitätsstraße 1, 40225 Düsseldorf, Germany; INVITE GmbH, Formulation Technology, Otto-Bayer-Straße 32, 51061 Köln, Germany.
Adv Drug Deliv Rev. 2025 Feb;217:115504. doi: 10.1016/j.addr.2024.115504. Epub 2024 Dec 19.
Three-dimensional (3D) printing, also referred to as additive manufacturing, is considered to be a game-changing technology in many industries and is also considered to have potential use cases in pharmaceutical manufacturing, especially if individualization is desired. In this review article the authors systematically researched literature published during the last 5 years (2019 - spring 2024) on the topic of 3D printed dosage forms. Besides all kinds of oral dosage forms ranging from tablets and capsules to films, pellets, etc., numerous reports were also identified on parenteral and cutaneous dosage forms and also rectal, vaginal, dental, intravesical, and ophthalmic preparations. In total, more than 500 publications were identified and grouped according to the site of administration, and an overview of the manuscripts is presented here. Furthermore, selected publications are described and discussed in more detail. The review highlights the very different approaches that are currently used in order to develop 3D printed dosage forms but also addresses remaining challenges.
三维（3D）打印，也称为增材制造，在许多行业中被视为一项改变游戏规则的技术，在制药生产中也被认为具有潜在的应用案例，特别是在需要个性化的情况下。在这篇综述文章中，作者系统地研究了过去5年（2019年至2024年春季）发表的关于3D打印剂型主题的文献。除了从片剂、胶囊到薄膜、微丸等各种口服剂型外，还发现了许多关于肠胃外和皮肤剂型以及直肠、阴道、牙科、膀胱内和眼科制剂的报道。总共确定了500多篇出版物，并根据给药部位进行了分类，在此展示了这些手稿的概述。此外，还对选定的出版物进行了更详细的描述和讨论。该综述强调了目前用于开发3D打印剂型的非常不同的方法，但也解决了仍然存在的挑战。
