Bagde Arvind, Messiha Mina, Singh Mandip
Pharmaceutical Sciences Department, Florida A&M University, Tallahassee, FL 32307, USA.
Gels. 2025 Mar 8;11(3):189. doi: 10.3390/gels11030189.
Oropharyngeal dysphagia and pain are prevalent concerns in the geriatric population. Therefore, this study investigates advances in the development of cannabidiol (CBD) gummies using 3D printing technology and compares them to commercially available molded gummies for pain management. A gelatin-based CBD formulation was prepared and printed using a syringe-based extrusion 3D printer. The formulation's rheological properties were assessed, and the printed gummies were characterized using a texture analyzer. Drug content was analyzed using HPLC, and in vitro dissolution studies were conducted in phosphate buffer (pH 1.2 and 6.8). Our results demonstrated that the gelatin-based formulation had shear-thinning rheological properties for 3D printing at a temperature of 38.00 °C, filament diameter of 26 mm and flow of 110%. The optimized printing parameters produced gummies with higher elasticity compared to marketed gummies and comparable toughness. Drug content analysis showed 98.14 ± 1.56 and 97.97 ± 2.14% of CBD in 3D-printed and marketed gummies, respectively. Dissolution studies revealed that both gummy types released 100% of the drug within 30 min in both pH 1.2 and 6.8 buffers. Overall, 3D printing enables customizable CBD gummies with optimized release and offer a personalized and patient-friendly alternative to traditional oral forms for geriatric care.
口咽吞咽困难和疼痛是老年人群中普遍存在的问题。因此，本研究调查了使用3D打印技术开发大麻二酚（CBD）软糖的进展，并将其与市售的模制软糖用于疼痛管理进行比较。制备了基于明胶的CBD制剂，并使用基于注射器的挤出式3D打印机进行打印。评估了该制剂的流变学性质，并使用质地分析仪对打印出的软糖进行了表征。使用高效液相色谱法分析药物含量，并在磷酸盐缓冲液（pH 1.2和6.8）中进行体外溶出研究。我们的结果表明，基于明胶的制剂在38.00°C的温度、26mm的长丝直径和110%的流速下具有适用于3D打印的剪切变稀流变学性质。与市售软糖相比，优化后的打印参数生产出的软糖具有更高的弹性和相当的韧性。药物含量分析显示，3D打印软糖和市售软糖中CBD的含量分别为98.14±1.56%和97.97±2.14%。溶出研究表明，两种类型的软糖在pH 1.2和6.8的缓冲液中均在30分钟内释放了100%的药物。总体而言，3D打印能够制造出具有优化释放的可定制CBD软糖，并为老年护理提供一种个性化且对患者友好的传统口服剂型替代方案。
