Epidemiology and Clinical Features of Bloodstream Infections: A 10-Year Retrospective Study in a Korean Teaching Hospital.

species are major pathogens of bloodstream infections (BSIs) in hospitalized patients, with high mortality. This study examined species distribution, clinical characteristics, and the mortality of patients with BSIs. Adult patients (≥16 years) with BSIs at a teaching hospital (2014-2023) were retrospectively reviewed. Over 10 years, 487 isolates were obtained from 462 patients. was the most frequent (38.2%), followed by (21.1%), (20.5%), and (13.3%). The annual incidence of BSIs remained stable ( = 0.525). However, non- species BSIs increased 1.61-fold compared to (95% CI: 1.19-2.19, = 0.002). Fluconazole-non-susceptible isolates increased after 2021 ( = 0.040). The overall 30-day mortality was 40.6%. In the multivariate analysis, a high Charlson comorbidity index (aHR: 1.20, 95% CI: 1.07-1.35, = 0.001) and high SOFA score (aHR: 1.12, 95% CI: 1.02-1.23, = 0.022) were the strongest predictors of 30-day mortality. Meanwhile, BSIs (aHR: 0.46, 95% CI: 0.22-0.99, = 0.047) and central venous catheter removal at any time (aHR: 0.22, 95% CI: 0.13-0.37, < 0.001) were associated with reduced 30-day mortality. The mortality of patients with BSIs was mainly determined by disease severity, while catheter removal was associated with improved survival.