Matathias O, Sohmer H, Biton V
Acta Otolaryngol. 1985 Mar-Apr;99(3-4):369-76. doi: 10.3109/00016488509108925.
In 43 multiple sclerosis (MS) patients and an equal number of age- and sex-matched normal controls, auditory nerve-brainstem evoked responses (ABR), audiometric tests, central auditory tests (CAT) and clinical-neurological examinations were conducted. The CAT included rapid alternating speech perception, masking level differences to tones and to words and lateralization based on interaural time and intensity differences. The results in the MS group on the ABR and each of the CAT differed significantly from those in the control group. The ABR results and the lateralization test results were each abnormal in 50% of the MS patients. The ABR, CAT and clinical examination results were all mutually correlated. These findings are probably related to the fact that the demyelination in MS induces a decrease in impulse velocity, to temporal dispersion and to desynchrony of impulses in groups of affected axons and to the fact that the ABR and the CAT tests chosen are dependent on synchronous impulse firing and on the precise timing of the arrival of impulses from each ear at some brain centre. These tests may therefore contribute to neurological and to audiological diagnosis.
对43例多发性硬化症（MS）患者以及数量相等的年龄和性别匹配的正常对照者进行了听神经-脑干诱发反应（ABR）、听力测试、中枢听觉测试（CAT）和临床神经学检查。CAT包括快速交替言语感知、对音调及单词的掩蔽级差以及基于双耳时间和强度差异的声源定位。MS组的ABR结果以及各项CAT结果与对照组相比均有显著差异。50%的MS患者ABR结果和声源定位测试结果均异常。ABR、CAT和临床检查结果相互关联。这些发现可能与以下事实有关：MS中的脱髓鞘会导致冲动速度降低、时间弥散以及受影响轴突组中冲动的不同步，还与所选的ABR和CAT测试依赖于同步冲动发放以及双耳冲动到达某个脑中枢的精确时间有关。因此，这些测试可能有助于神经学和听力学诊断。
