Maurer K, Schäfer E, Hopf H C, Leitner H
J Neurol. 1980;223(1):43-58. doi: 10.1007/BF00313139.
Tone pips of suprathreshold intensities elicit an acoustic nerve response (I) and six low amplitude brainstem potentials (II-VII) during the initial 10 ms. Seven waves were studied in 40 control subjects and 5 waves (I-V) in 47 patients with MS. The results suggest involvement of the auditory pathway of 24 of 27 patients in the clinically "definite", of 5 of 9 cases in the "probable" and in none of 5 patients in the "possible" MS groups. EAEPs were normal in 6 cases with a spinal form with one exception where changes of potential were indicative of a midbrain lesion. Dysfunction within the acoustic pathway was observed at the level of the acoustic nerve and in the medulla oblongata, pons and midbrain. The significance of the bilateral EAEP abnormalities found in some patients at different levels is discussed with regard to a polytopic location of the underlying lesion.
阈上强度的短纯音在最初10毫秒内引发听神经反应（I）和六个低振幅脑干电位（II - VII）。在40名对照受试者中研究了七个波，在47名多发性硬化症患者中研究了五个波（I - V）。结果表明，在临床“确诊”的27例患者中有24例、“可能”的9例中有5例以及“疑似”的5例患者中无一例听觉通路受累。6例脊髓型患者的听觉诱发电位正常，只有1例电位变化提示中脑病变。在听神经以及延髓、脑桥和中脑水平观察到听觉通路功能障碍。针对一些患者在不同水平发现的双侧听觉诱发电位异常的意义，结合潜在病变的多灶性位置进行了讨论。
