Mereddy Rishith R, Zona Emily E, LaLiberte Camille J, Dingle Aaron M
Division of Plastic and Reconstructive Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.
J Funct Biomater. 2025 Mar 11;16(3):97. doi: 10.3390/jfb16030097.
Zone II flexor digitorum profundus (FDP) tendon injuries are complex, and present significant challenges in hand surgery, due to the need to balance strength and flexibility during repair. Traditional suture techniques often lead to complications such as adhesions or tendon rupture, prompting the exploration of novel strategies to improve outcomes. This review investigates the use of flexor digitorum superficialis (FDS) tendon autografts to reinforce FDP repairs, alongside the integration of biomaterials to enhance mechanical strength without sacrificing FDS tissue. Key biomaterials, including collagen-polycaprolactone (PCL) composites, are evaluated for their biocompatibility, mechanical integrity, and controlled degradation properties. Collagen-PCL emerges as a leading candidate, offering the potential to reduce adhesions and promote tendon healing. Although nanomaterials such as nanofibers and nanoparticles show promise in preventing adhesions and supporting cellular proliferation, their application remains limited by manufacturing challenges. By combining advanced repair techniques with biomaterials like collagen-PCL, this approach aims to improve surgical outcomes and minimize complications. Future research will focus on validating these findings in biological models, assessing tendon healing through imaging, and comparing the cost-effectiveness of biomaterial-enhanced repairs with traditional methods. This review underscores the potential for biomaterial-based approaches to transform FDP tendon repair.
II区指深屈肌腱（FDP）损伤情况复杂，在手外科手术中带来了重大挑战，因为在修复过程中需要平衡力量和灵活性。传统的缝合技术常常导致诸如粘连或肌腱断裂等并发症，促使人们探索新的策略来改善治疗效果。这篇综述研究了使用指浅屈肌腱（FDS）自体移植物来加强FDP修复，以及整合生物材料以在不牺牲FDS组织的情况下提高机械强度。对包括胶原蛋白-聚己内酯（PCL）复合材料在内的关键生物材料的生物相容性、机械完整性和可控降解特性进行了评估。胶原蛋白-PCL成为主要候选材料，具有减少粘连和促进肌腱愈合的潜力。尽管纳米纤维和纳米颗粒等纳米材料在防止粘连和支持细胞增殖方面显示出前景，但其应用仍受制造难题的限制。通过将先进的修复技术与胶原蛋白-PCL等生物材料相结合，这种方法旨在改善手术效果并将并发症降至最低。未来的研究将集中在生物模型中验证这些发现，通过成像评估肌腱愈合情况，并比较生物材料增强修复与传统方法的成本效益。这篇综述强调了基于生物材料的方法在改变FDP肌腱修复方面的潜力。
