环境污染物混合物与红细胞叶酸浓度的关联：基于2007 - 2016年美国国家健康与营养检查调查（NHANES）数据的美国成年人群体混合分析

Associations of Environmental Pollutant Mixtures and Red Blood Cell Folate Concentrations: A Mixture Analysis of the U.S. Adult Population Based on NHANES Data, 2007-2016.

作者信息

Mascari Michael, Reeves Katherine, Balasubramanian Raji, Liu Zhenhua, Laouali Nasser, Oulhote Youssef

机构信息

Department of Epidemiology and Biostatistics, School of Public Health & Health Sciences, University of Massachusetts Amherst, Amherst, MA 01003, USA.

Department of Nutrition, School of Public Health & Health Sciences, University of Massachusetts Amherst, Amherst, MA 01003, USA.

出版信息

Toxics. 2025 Mar 11;13(3):200. doi: 10.3390/toxics13030200.

DOI:10.3390/toxics13030200

PMID:40137527

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11945967/

Abstract

BACKGROUND

Folate is critical for many physiological processes, and low folate levels have been associated with a wide range of health outcomes, including chronic diseases and developmental outcomes. Many environmental chemicals are suspected to contribute to the etiology of health outcomes related to folate deficiency. However, little is known about how these pollutants influence folate levels as potential mechanistic pathways.

OBJECTIVE

To investigate the individual and joint associations between a mixture of 39 pollutants and red blood cell (RBC) folate concentrations in the U.S.

METHODS

We used available data on 27,938 participants, aged 18-80 from the U.S. National Health and Nutrition Examination survey (2007-2016), with available RBC folate concentrations and 39 environmental pollutants' concentrations. We estimated covariate-adjusted independent and joint associations between environmental pollutants and RBC folate, and compared evidence from two complimentary mixture approaches: exposome-wide association study (ExWAS) and quantile-based g computation (Q-gcomp).

RESULTS

In the ExWAS analysis, 12 environmental chemicals, including metals (cadmium, arsenic, lead, and mercury), perfluoroalkyl substances, phthalates, phenols and parabens, and polycyclic aromatic hydrocarbons, were inversely associated with RBC folate, whereas four environmental pollutants, including metals (manganese and selenium) and two phthalate metabolites, were positively associated with RBC folate. Q-gcomp showed convergent results with the ExWAS analysis; a quartile increase in the metal and PFAS mixtures was significantly associated with a decrease of -38.4 ng/mL (95%CI: -52.3, -24.4) and -48.9 ng/mL (95%CI: -57.6, -39.6) in RBC folate concentrations, respectively.

CONCLUSION

The present study shows that higher exposure to PFASs, metals, and PAHs are associated with lower RBC folate concentrations. However, given the cross-sectional design, we cannot make inferences about the directionality of the observed associations.

摘要

背景

叶酸对许多生理过程至关重要，低叶酸水平与广泛的健康结果相关，包括慢性疾病和发育结局。许多环境化学物质被怀疑与叶酸缺乏相关的健康结果的病因有关。然而，对于这些污染物如何作为潜在的作用机制途径影响叶酸水平知之甚少。

目的

研究美国39种污染物混合物与红细胞（RBC）叶酸浓度之间的个体和联合关联。

方法

我们使用了来自美国国家健康与营养检查调查（2007 - 2016年）的27938名年龄在18 - 80岁参与者的现有数据，这些数据包含红细胞叶酸浓度和39种环境污染物的浓度。我们估计了环境污染物与红细胞叶酸之间经协变量调整的独立和联合关联，并比较了两种互补的混合物方法的证据：全暴露组关联研究（ExWAS）和基于分位数的g计算（Q - gcomp）。

结果

在ExWAS分析中，12种环境化学物质，包括金属（镉、砷、铅和汞）、全氟烷基物质、邻苯二甲酸盐、酚类和对羟基苯甲酸酯以及多环芳烃，与红细胞叶酸呈负相关，而4种环境污染物，包括金属（锰和硒）以及两种邻苯二甲酸酯代谢物，与红细胞叶酸呈正相关。Q - gcomp与ExWAS分析结果一致；金属和全氟辛烷磺酸混合物增加一个四分位数分别与红细胞叶酸浓度显著降低 - 38.4 ng/mL（95%CI： - 52.3， - 24.4）和 - 48.9 ng/mL（95%CI： - 57.6， - 39.6）相关。