Pór I
Acta Physiol Hung. 1985;65(3):255-62.
Alterations in the dorsal root potential (DRP) which was evoked by stimulation of the common peroneal nerve of the rat, have been studied in the course of transganglionic degenerative atrophy (TDA) of primary sensory terminals in the upper dorsal horn. TDA was induced by perineural application of Vinca alkaloids around the sciatic nerve. In 9 to 30 days after this treatment, latency of DRP increased, whereas its amplitude and duration decreased. In this period, no C fibre response could be elicited. As a possible mechanism underlying the alterations of DRP, the functional consequences of atrophic changes of primary central afferent terminals are being discussed in terms of the close correlation between structure and function and the possible inferences of the electrophysiological reaction to the therapeutic application of Vinca alkaloids in the iontophoretic treatment of chronic intractable pain.
在大鼠上背部脊髓后角初级感觉终末的跨节变性萎缩（TDA）过程中，研究了刺激大鼠腓总神经所诱发的背根电位（DRP）的变化。TDA是通过在坐骨神经周围经神经外膜应用长春花生物碱诱导产生的。在该处理后的9至30天内，DRP的潜伏期延长，而其幅度和持续时间缩短。在此期间，无法引出C纤维反应。作为DRP变化的一种可能机制，根据结构与功能之间的密切相关性以及电生理反应对长春花生物碱在慢性顽固性疼痛离子导入治疗中的治疗应用的可能推断，正在讨论初级中枢传入终末萎缩性变化的功能后果。
