Tajti J, Penke B, Kovács K, Csillik B
Department of Anatomy, Szent-Györgyi Albert Medical University, Szeged, Hungary.
Acta Morphol Hung. 1988;36(1-2):7-14.
In addition to the classical microtubule inhibitors (antimitotic agents), transganglionic degenerative atrophy of central terminals of primary sensory neurons can be induced also by means of applying to a peripheral nerve basic polypeptides (Polymyxin B and Colimycin) and two basic derivatives of glutamic acid that do not exert any microtubule inhibition. This effect is independent of other pharmacological effects (histamine liberation, Ca2+ -binding, etc.) of the applied compounds, and probably it is based on a competitive reaction with nerve growth factor.
除了经典的微管抑制剂（抗有丝分裂剂）外，通过向周围神经施加碱性多肽（多粘菌素B和粘菌素）以及两种不具有任何微管抑制作用的谷氨酸碱性衍生物，也可诱导初级感觉神经元中枢终末的跨神经节变性萎缩。这种作用独立于所施加化合物的其他药理作用（组胺释放、Ca2+结合等），并且可能基于与神经生长因子的竞争性反应。
