Csillik B, Knyihár-Csillik E, Tajti J
Acta Biol Acad Sci Hung. 1982;33(2-3):149-56.
If applied locally around a peripheral sensory nerve, Formyl-Leurosin, a semi-synthetic diindol alkaloid of Vinca rosea--that, just like other mitotic spindle inhibitors, induces blockade of axoplasmic transport via inhibiting microtubular function--causes transganglionic degenerative atrophy of central terminals of primary nociceptive neurons in the substantia gelatinosa Rolandi of the spinal cord. In contrast, if applied to dorsal roots, Formyl-Leurosin fails to induce such alterations. Based upon these observations it is postulated that blockade of retrograde axoplasmic transport, rather than that of the orthograde one, is the decisive factor in the pathomechanism of transganglionic degenerative atrophy.
如果在外周感觉神经周围局部应用长春花的半合成二吲哚生物碱甲酰长春质碱（它与其他有丝分裂纺锤体抑制剂一样，通过抑制微管功能诱导轴浆运输阻滞），会导致脊髓胶状质中初级伤害性神经元的中枢终末发生跨节段性退行性萎缩。相比之下，如果将甲酰长春质碱应用于背根，则不会诱导这种改变。基于这些观察结果，推测逆行性轴浆运输的阻滞而非顺行性轴浆运输的阻滞是跨节段性退行性萎缩发病机制中的决定性因素。
