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与乙酰水杨酸相比，水杨酸钠可预防再喂养大鼠中由吲哚美辛引起的胃窦和肠道溃疡。

Sodium-salicylate in contrast with acetylsalicylic acid prevents gastric antral and intestinal ulcers produced by indomethacin in the refed rat.

作者信息

Ezer E

出版信息

Acta Physiol Hung. 1985;65(3):263-6.

PMID:4013765
Abstract

Indomethacin produced true ulcers; the lesions penetrated into the muscularis mucosae of the antrum of refed rats and into the intestine of both refed and conventionally fed rats. Sodium-salicylate dose-dependently and simultaneously prevented the antral and intestinal ulcers produced by indomethacin in refed rats. Acetylsalicylic acid had no preventive effect on small intestinal ulcers and markedly increased the indomethacin induced antral ulcers.

摘要

吲哚美辛可导致真正的溃疡；这些损伤穿透了再喂养大鼠胃窦部的黏膜肌层以及再喂养和常规喂养大鼠的肠道。水杨酸钠呈剂量依赖性且同时预防了再喂养大鼠中由吲哚美辛引起的胃窦和肠道溃疡。乙酰水杨酸对小肠溃疡没有预防作用，反而显著增加了吲哚美辛诱导的胃窦溃疡。

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1
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Acta Physiol Hung. 1985;65(3):263-6.
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