Beró T, Németh A, Mózsik G, Jávor T
Acta Physiol Hung. 1984;64(3-4):343-7.
The effect of various gastric cytoprotective drugs was studied on the development of indomethacin induced intestinal ulcers. CFY strain rats weighing 200-250 g were used. Indomethacin in a single dose of 20 mg/kg was given intragastrically in 1.5 ml. The animals received atropine (0.025-0.2-1.0 mg/kg), cimetidine (2.5-10-50 mg/kg) or vitamin-A(0.1-1.0-10 mg/kg) intraperitoneally in a single dose 15 min before the administration of indomethacin. In another study the animals received the same doses of atropine twice a day for 3 days. The small intestine was examined for lesions consisting of: (a) palpable nodules on the mesenteric attachement: (b) ulcers in the jejunum and ileum: (c) adhesions as a consequence of ulcer perforation. Neither histamin H2 receptor antagonists, anticholinergics, nor vitamin-A affected the number and the severity of the indomethacin induced intestinal ulcers. These results suggest that, whereas atropine, cimetidine and vitamin-A have a cytoprotecting effect in the stomach, it appears that they have no role in intestinal cytoprotection.
研究了各种胃细胞保护药物对消炎痛诱导的肠道溃疡发生发展的影响。使用体重为200 - 250克的CFY品系大鼠。将单剂量20毫克/千克的消炎痛以1.5毫升体积灌胃给药。在给予消炎痛前15分钟，动物腹腔注射单剂量的阿托品（0.025 - 0.2 - 1.0毫克/千克）、西咪替丁（2.5 - 10 - 50毫克/千克）或维生素A（0.1 - 1.0 - 10毫克/千克）。在另一项研究中，动物每天两次接受相同剂量的阿托品，共3天。检查小肠的病变包括：（a）肠系膜附着处可触及的结节；（b）空肠和回肠的溃疡；（c）溃疡穿孔导致的粘连。组胺H2受体拮抗剂、抗胆碱能药物和维生素A均未影响消炎痛诱导的肠道溃疡的数量和严重程度。这些结果表明，虽然阿托品西咪替丁和维生素A在胃中有细胞保护作用，但它们似乎在肠道细胞保护中不起作用。
