Cui Yingying, Li Wei, Li Binbin
Department of Oral Pathology, Peking University School and Hospital of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing 100081, China.
Research Unit of Precision Pathologic Diagnosis in Tumors of the Oral and Maxillofacial Regions, Chinese Academy of Medical Sciences, Beijing 100081, China.
Pathogens. 2025 Mar 15;14(3):289. doi: 10.3390/pathogens14030289.
Human-papillomavirus-positive oropharyngeal squamous cell carcinoma (HPV-positive OPSCC) is a distinct disease characterized by unique clinical and molecular features compared to HPV-negative OPSCC. A comprehensive bibliometric analysis of HPV-positive OPSCC research was conducted in this study to identify key trends, research hotspots, and emerging frontiers in the field. Data were retrieved from the Web of Science Core Collection database. The distributions of contributors, including countries, institutions, authors, journals, and cooperative networks related to HPV-positive OPSCC, were analyzed and visualized using VOSviewer 1.6.20, CiteSpace 6.3.R1, and the R package Bibliometrix 4.0.0. In addition, the most influential publications and high-frequency keywords were identified and analyzed to discern key topics in this field. A total of 3895 articles and reviews on HPV-positive OPSCC were identified, involving 106 countries, 620 journals, and 18949 authors. The main contributors include the USA (1908 publications), Johns Hopkins University (310 publications), the journal Head and Neck (320 publications), and Erich M. Sturgis (94 publications). The top three keywords are "survival", "radiotherapy", and "p16". There has been a steadily increasing research interest in HPV-positive OPSCC over the last 23 years. Current studies focus on diagnosis, treatment strategies, prognosis, recurrence, and disease surveillance. This bibliometric analysis highlights key contributors and emerging themes, offering insights for future research directions.
人乳头瘤病毒阳性口咽鳞状细胞癌（HPV阳性OPSCC）是一种与HPV阴性OPSCC相比具有独特临床和分子特征的独特疾病。本研究对HPV阳性OPSCC研究进行了全面的文献计量分析，以确定该领域的关键趋势、研究热点和新兴前沿。数据从Web of Science核心合集数据库中检索。使用VOSviewer 1.6.20、CiteSpace 6.3.R1和R包Bibliometrix 4.0.0对与HPV阳性OPSCC相关的贡献者分布进行了分析和可视化，包括国家、机构、作者、期刊和合作网络。此外，还确定并分析了最具影响力的出版物和高频关键词，以辨别该领域的关键主题。共识别出3895篇关于HPV阳性OPSCC的文章和综述，涉及106个国家、620种期刊和18949名作者。主要贡献者包括美国（1908篇出版物）、约翰霍普金斯大学（310篇出版物）、《头颈》杂志（320篇出版物）和埃里希·M·斯特吉斯（94篇出版物）。排名前三的关键词是“生存”、“放疗”和“p16”。在过去23年中，对HPV阳性OPSCC的研究兴趣一直在稳步增加。当前的研究集中在诊断、治疗策略、预后、复发和疾病监测方面。这项文献计量分析突出了关键贡献者和新兴主题，为未来的研究方向提供了见解。
