Jilin Provincial Key Laboratory of Radiation Oncology and Therapy, The First Hospital of Jilin University and College of Basic Medical Science, Jilin University, Changchun, China.
Department of Radiation Oncology, The First Hospital of Jilin University, Changchun, China.
J Cell Mol Med. 2024 Oct;28(19):e70073. doi: 10.1111/jcmm.70073.
Human papillomavirus (HPV) infection is a causative factor in the occurrence and progression of oropharyngeal squamous cell carcinoma (OPSCC). In recent years, clinical studies have found that HPV-positive OPSCC patients may present a better prognosis than HPV-negative patients, yet the underlying causes are unclear. This study aimed to investigate the relevance of HPV infection and the prognosis of OPSCC. On this basis, we aimed to establish a prediction model to accurately predict the prognosis and guide clinical practice. We analysed the records of 233 patients with OPSCC. Cox regression was applied to identify factors associated with survival. Moreover, variables with significant discrepancies were integrated into a nomogram model to predict prognosis. The results showed that HPV was an independent prognostic factor for OS and PFS. Immunoglobulin Heavy Constant Mu (IGHM) mRNA was significantly upregulated in patients with HPV-positive OPSCC. Crucially, IGHM expression was associated with better prognosis. The receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis both confirmed that the prognostic model exhibits good performance. In summary, HPV infection were independent prognostic factors for OPSCC. IGHM may be the key contributors to the prognostic differences in HPV-associated OPSCC. This nomogram model was able to accurately predict the prognosis of patients.
人乳头瘤病毒（HPV）感染是口咽鳞状细胞癌（OPSCC）发生和进展的一个致病因素。近年来，临床研究发现 HPV 阳性 OPSCC 患者的预后可能优于 HPV 阴性患者，但具体原因尚不清楚。本研究旨在探讨 HPV 感染与 OPSCC 预后的相关性。在此基础上，我们旨在建立一个预测模型，以准确预测预后并指导临床实践。我们分析了 233 例 OPSCC 患者的记录。应用 Cox 回归分析确定与生存相关的因素。此外，将具有显著差异的变量整合到列线图模型中以预测预后。结果表明，HPV 是 OS 和 PFS 的独立预后因素。HPV 阳性 OPSCC 患者的免疫球蛋白重链恒定 Mu（IGHM）mRNA 表达明显上调。重要的是，IGHM 表达与较好的预后相关。受试者工作特征（ROC）曲线、校准曲线和决策曲线分析均证实了该预后模型具有良好的性能。总之，HPV 感染是 OPSCC 的独立预后因素。IGHM 可能是 HPV 相关 OPSCC 预后差异的关键因素。该列线图模型能够准确预测患者的预后。
