Alberdi-Garciandia Aitor, Santos-Concejero Jordan
Department of Physical Education and Sport, University of the Basque Country UPV/EHU, 01007 Vitoria-Gasteiz, Spain.
Sports (Basel). 2025 Mar 6;13(3):78. doi: 10.3390/sports13030078.
The use of recombinant human erythropoietin (rHuEPO) has been found to improve different cardiopulmonary-related variables that ultimately enhance endurance performance. The main goal of this systematic review was to analyze the hematological, physiological, and performance effects (both maximal and submaximal) of rHuEPO in well-trained endurance athletes. A literature search was conducted in three different databases (PubMed, Web of Science, and Scopus) on 20 January 2025; including studies published from 1 January 2010 to the search date. After analyzing 985 resultant articles and 5 records identified outside of the databases through citation tracking, 10 studies that met the inclusion criteria were included in the systematic review. We found that, regardless of the total dose of rHuEPO used, this substance improves the main hematological (total hemoglobin mass, hemoglobin concentration, and hematocrit) and physiological (maximal oxygen uptake and peak oxygen uptake) parameters, while the maximal performance-related parameters (mainly, maximal power output, and peak power output) also tend to increase. However, further research is needed to determine if rHuEPO can also improve submaximal parameters, which are also major determinants of performance in endurance sports.
已发现使用重组人促红细胞生成素（rHuEPO）可改善不同的心肺相关变量，最终提高耐力表现。本系统评价的主要目的是分析rHuEPO对训练有素的耐力运动员的血液学、生理学及表现（最大和次最大）影响。于2025年1月20日在三个不同数据库（PubMed、科学网和Scopus）进行文献检索，包括2010年1月1日至检索日期发表的研究。在分析了985篇所得文章以及通过引文追踪在数据库外识别出的5条记录后，10项符合纳入标准的研究被纳入该系统评价。我们发现，无论使用的rHuEPO总剂量如何，该物质均可改善主要血液学参数（总血红蛋白量、血红蛋白浓度和血细胞比容）和生理学参数（最大摄氧量和峰值摄氧量），同时与最大表现相关的参数（主要是最大功率输出和峰值功率输出）也往往会增加。然而，需要进一步研究以确定rHuEPO是否还能改善次最大参数，这些参数也是耐力运动表现的主要决定因素。
