Zhou X, Shu Z G, Liu S C, Li D Z
Department of Neurosurgery, Quzhou Hospital of Traditional Chinese Medicine, Quzhou City, Zhejiang Province, 324000, China.
Department of Neurology, Ezhou Central Hospital, Ezhou City, Hubei Province, 436000, China.
J Physiol Pharmacol. 2025 Feb;76(1). doi: 10.26402/jpp.2025.1.03. Epub 2025 Mar 18.
This study investigated the effect of edaravone dexborneol (ED) combined with interventional thrombectomy in the treatment of ischemic stroke (IS) in the elderly and its effects on nerve function, cerebral hemodynamic status, and levels of serum amyloid A (SAA), lipoprotein-associated phospholipase A2 (LP-PLA2), and soluble CD40 ligand (sCD40L). One hundred elderly patients with IS were divided into the control group and observation group by random number table method. The control group received conventional treatment after interventional thrombectomy, and the observation group received conventional treatment and ED treatment after interventional thrombectomy. After 14 days of treatment, the therapeutic effect was evaluated according to the National Institutes of Health Stroke Scale (NIHSS). Neurological function, serum brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), neuron-specific enolase (NSE), cerebral haemodynamics, indices of oxidative stress, and serum levels of SAA, LP-PLA2, and sCD40L before and after treatment in both groups were compared. The total effective rate of clinical efficacy was higher and the NIHSS score was lower in the observation group than in the control group (P<0.05). The observation group exhibited higher mean blood velocity and mean blood flow, alongside lower characteristic impedance and dynamic resistance, compared to the control group (P<0.05). SAA, LP-PLA2, and sCD40L in the observation group were lower than those in the control group (P<0.05). BDNF, NGF, and SOD in the observation group were higher than those in the control group, and NSE, MDA, and NEF were lower (P<0.05). ED combined with interventional thrombectomy in the treatment of IS in the elderly can improve nerve function, alleviate oxidative stress reaction, reduce levels of SAA, LP-PLA2, and sCD40L, and alleviate inflammatory response.
本研究探讨依达拉奉右莰醇（ED）联合介入取栓术治疗老年缺血性脑卒中（IS）的疗效及其对神经功能、脑血流动力学状态以及血清淀粉样蛋白A（SAA）、脂蛋白相关磷脂酶A2（LP-PLA2）和可溶性CD40配体（sCD40L）水平的影响。将100例老年IS患者采用随机数字表法分为对照组和观察组。对照组在介入取栓术后接受常规治疗，观察组在介入取栓术后接受常规治疗及ED治疗。治疗14天后，根据美国国立卫生研究院卒中量表（NIHSS）评估治疗效果。比较两组治疗前后的神经功能、血清脑源性神经营养因子（BDNF）、神经生长因子（NGF）、神经元特异性烯醇化酶（NSE）、脑血流动力学、氧化应激指标以及SAA、LP-PLA2和sCD40L的血清水平。观察组临床疗效总有效率高于对照组，NIHSS评分低于对照组（P<0.05）。与对照组相比，观察组平均血流速度和平均血流量更高，特征阻抗和动态阻力更低（P<0.05）。观察组的SAA、LP-PLA2和sCD4L低于对照组（P<0.05）。观察组的BDNF、NGF和超氧化物歧化酶（SOD）高于对照组，NSE、丙二醛（MDA）和去甲肾上腺素（NEF）低于对照组（P<0.05）。ED联合介入取栓术治疗老年IS可改善神经功能，减轻氧化应激反应，降低SAA、LP-PLA2和sCD40L水平，并减轻炎症反应。
