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右莰醇依达拉奉与依达拉奉治疗急性脑梗死的Meta分析

Edaravone dexborneol compared to edaravone in the treatment of acute cerebral infarction: A meta-analysis.

作者信息

Shi Yanshuo, Yue Yuanyuan, Wang Mi, Wu Huizhen

机构信息

Department of Pharmacy, Hebei General Hospital, Shijiazhuang, China.

Hebei Key Laboratory of Clinical Pharmacy, Shijiazhuang, Hebei Province, China.

出版信息

Front Pharmacol. 2025 Jun 4;16:1579742. doi: 10.3389/fphar.2025.1579742. eCollection 2025.

DOI:10.3389/fphar.2025.1579742
PMID:40535767
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12174052/
Abstract

OBJECTIVE

The objective of this study was to systematically assess the clinical efficacy and safety of edaravone dexborneol compared to those of edaravone in treating acute cerebral infarction.

METHODS

We searched the PubMed, Cochrane Library, Embase, CBM, CNKI, Wanfang Database, and VIP to gather randomized controlled trials (RCTs) comparing edaravone dexborneol with edaravone for treating acute cerebral infarction, covering studies from the database inception to February 2024. After data extraction and quality evaluation, a meta-analysis was carried out using RevMan 5.3 and Stada 18.0 statistical software.

RESULTS

Seventeen RCTs were enrolled, including 2,778 patients, of which 1,493 and 1,285 were in the observation and control groups, respectively. The meta-analysis revealed that the total effective rate was significantly higher in the edaravone dexborneol group (RR = 1.17, 95% CI [1.11, 1.24], p < 0.00001) than in the edaravone group. Additionally, the rate of adverse reactions was significantly lower in the edaravone group (RR = 0.55, 95% CI [0.36, 0.82], p = 0.004). Fourteen days after treatment, the edaravone dexborneol group showed significantly better scores than the edaravone group in the NIHSS (MD = -2.13, 95% CI [-2.90, -1.35], p < 0.00001), Barthel Index (MD = 12.13, 95% CI [7.68, 16.58], p < 0.00001), and modified Rankin Scale (MD = -1.16, 95% CI [-1.75, -0.56], p = 0.0001).

CONCLUSION

Edaravone dexborneol demonstrates superior clinical efficacy and safety compared to edaravone in the treatment of acute cerebral infarction, suggesting it may be a more effective therapeutic option.

摘要

目的

本研究旨在系统评估右莰醇注射用丁基苯酞与依达拉奉治疗急性脑梗死的临床疗效和安全性。

方法

检索PubMed、Cochrane图书馆、Embase、中国生物医学文献数据库（CBM）、中国知网（CNKI）、万方数据库和维普数据库，收集比较右莰醇注射用丁基苯酞与依达拉奉治疗急性脑梗死的随机对照试验（RCT），涵盖从各数据库建库至2024年2月的研究。经过数据提取和质量评估，使用RevMan 5.3和Stada 18.0统计软件进行荟萃分析。

结果

纳入17项RCT，共2778例患者，其中观察组1493例，对照组1285例。荟萃分析显示，右莰醇注射用丁基苯酞组的总有效率显著高于依达拉奉组（RR = 1.17，95%CI [1.11, 1.24]，p < 0.00001）。此外，依达拉奉组的不良反应发生率显著较低（RR = 0.55，95%CI [0.36, 0.82]，p = 0.004）。治疗14天后，右莰醇注射用丁基苯酞组在神经功能缺损评分量表（NIHSS）（MD = -2.13，95%CI [-2.90, -1.35]，p < 0.00001）、Barthel指数（MD = 12.13，95%CI [7.68, 16.58]，p < 0.00001）和改良Rankin量表（MD = -1.16，95%CI [-1.75, -0.56]，p = 0.0001）方面的评分均显著优于依达拉奉组。

结论

在治疗急性脑梗死方面，右莰醇注射用丁基苯酞的临床疗效和安全性优于依达拉奉，表明它可能是一种更有效的治疗选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8cb/12174052/b2d387027059/fphar-16-1579742-g009.jpg
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