Zona Rubio Diana Carolina, Aragón Diana Marcela, Almeida Alves Izabel
Grupo de Investigación Cuidado Cardiorrespiratorio, Universidad Manuela Beltrán, Bogotá 110231, Colombia.
Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia, Bogotá 111321, Colombia.
Toxins (Basel). 2025 Mar 14;17(3):136. doi: 10.3390/toxins17030136.
Active compounds from natural sources, particularly snake venoms, are crucial for pharmaceutical development despite challenges in drug discovery. Snake venoms, historically used for medicinal purposes, contain bioactive peptides and enzymes that show therapeutic potential for conditions such as arthritis, asthma, cancer, chronic pain, infections and cardiovascular diseases. The objective of this study was to examine pharmacological and biomedical innovations by identifying the key research trends, the most studied snake species, and their therapeutic applications. A systematic review of patents related to snake venoms was conducted using the European Patent Office database, Espacenet, covering 2014 to mid-2024. The search employed the keyword "venom," applying IPC classification A61K38/00, resulting in 31 patents after screening. A PubMed survey on "snake venom derivatives innovations" was conducted to compare the scientific literature volume with the identified patents. This review highlights the therapeutic potential of snake venom-derived products for coagulation disorders, cancer, inflammation, and pain management. Despite challenges in pharmacokinetics and venom variability, advancements in biotechnology offer promise for personalized therapies. The future of snake venom-based treatments appears promising for addressing complex medical conditions.
来自天然来源的活性化合物，尤其是蛇毒，尽管在药物发现方面存在挑战，但对药物开发至关重要。蛇毒在历史上被用于医学目的，含有生物活性肽和酶，对关节炎、哮喘、癌症、慢性疼痛、感染和心血管疾病等病症显示出治疗潜力。本研究的目的是通过确定关键研究趋势、研究最多的蛇种及其治疗应用，来考察药理学和生物医学创新。使用欧洲专利局数据库Espacenet对2014年至2024年年中与蛇毒相关的专利进行了系统综述。检索采用关键词“毒液”，应用国际专利分类A61K38/00，筛选后得到31项专利。对“蛇毒衍生物创新”进行了PubMed调查，以将科学文献量与已确定的专利进行比较。本综述强调了蛇毒衍生产品在凝血障碍、癌症、炎症和疼痛管理方面的治疗潜力。尽管在药代动力学和毒液变异性方面存在挑战，但生物技术的进步为个性化治疗带来了希望。基于蛇毒的治疗方法在解决复杂医疗状况方面的前景似乎很广阔。
