前列腺癌的靶向和区域活检：首个真实世界数据。
Targeted and regional biopsy in prostate cancer: first real-world data.
作者信息
Long-Depaquit Thibaut, Corral Renaud, Uleri Alessandro, Peyrottes Arthur, Campagna Jennifer, Toledano Harry, Bastide Cyrille, Baboudjian Michael
机构信息
Department of Urology, HIA Sainte-Anne, Toulon, France.
Department of Urology, AP-HM, North Hospital, Marseille, France.
出版信息
World J Urol. 2025 Mar 26;43(1):187. doi: 10.1007/s00345-025-05585-6.
INTRODUCTION
MRI-targeted biopsies enhance prostate cancer (PCa) diagnostics, but systematic distant biopsies increase overdiagnosis and overtreatment. Regional biopsies may optimize diagnostic efficiency.
METHODS
This prospective single-center study included biopsy-naïve patients undergoing transperineal MRI-guided biopsies with cognitive fusion and regional sampling.
RESULTS
Among 50 patients, 66% had clinically significant PCa, 16% insignificant PCa, and 18% no cancer. No re-biopsies were needed for non-cancerous cases. Of 12 patients undergoing nerve-sparing radical prostatectomy, 25% had a bilateral disease, with two positive margins.
CONCLUSION
This novel biopsy template may help reduce unnecessary sampling and associated risks. Larger comparative studies are needed to confirm these findings.
引言
磁共振成像（MRI）靶向活检可提高前列腺癌（PCa）的诊断水平，但系统性远处活检会增加过度诊断和过度治疗的情况。区域性活检可能会优化诊断效率。
方法
这项前瞻性单中心研究纳入了未经活检的患者，这些患者接受了经会阴MRI引导下的认知融合和区域采样活检。
结果
在50例患者中，66%患有临床显著性PCa，16%患有非显著性PCa，18%未患癌症。非癌症病例无需再次活检。在12例接受保留神经的根治性前列腺切除术的患者中，25%患有双侧疾病，其中两例切缘阳性。
结论
这种新型活检模板可能有助于减少不必要的采样及相关风险。需要开展更大规模的对比研究来证实这些发现。
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