Y染色体造血缺失与心房颤动发病率及性别差异的关联
Association of Hematopoietic Loss of Y Chromosome With Atrial Fibrillation Incidence and Sex Disparity.
作者信息
Ma Tianqi, Zhu Chen, Cheng Xunjie, Huang Yuanfeng, Li Jinchen, Tan Yu, Bai Yongping
机构信息
Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, China; Center of Coronary Circulation, Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, China; Center of Coronary Circulation, Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China; Department of Geriatric Medicine, Xiangya Hospital, Central South University, Changsha, China.
出版信息
JACC Basic Transl Sci. 2025 Mar;10(3):279-289. doi: 10.1016/j.jacbts.2024.10.012. Epub 2025 Jan 15.
Mosaic loss of chromosome Y (mLOY), the most common somatic mutation, prompts fibrotic heart diseases. We hypothesized that it accelerates atrial fibrillation (AF) and contributes to its sex disparity. A total of 214,405 male participants from the UK Biobank without prevalent AF were included, with a median follow-up of 14.31 years. mLOY was associated with a 16% higher AF risk, with 9.6% and 6.4% of the association mediated by neutrophils and monocytes. AF risk of males with mLOY was 98% higher than that of matched females. Thus, mLOY is associated with a slightly increased AF risk, and might partly contribute to sex disparity of AF.
Y染色体嵌合缺失（mLOY）是最常见的体细胞突变，可引发心脏纤维化疾病。我们推测，它会加速心房颤动（AF）并导致其性别差异。研究纳入了英国生物银行中214,405名无AF病史的男性参与者，中位随访时间为14.31年。mLOY与AF风险高16%相关，其中9.6%和6.4%的关联由中性粒细胞和单核细胞介导。患有mLOY的男性发生AF的风险比匹配的女性高98%。因此，mLOY与AF风险略有增加相关，可能部分导致了AF的性别差异。
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