用于减轻新型禽流感病毒影响的新型通用疫苗。

Novel universal vaccines to mitigate emerging avian influenza viruses.

作者信息

Liu Yu, Wang Lifang, Lai Alexander, Kang Mei, Qi Yangrui, Merits Andres, Jiao Xinyi, Wang Xinyu, Yu Xiangrong, Su Shuo, Jiang Zhiwen

机构信息

Department of Radiology, Zhuhai Clinical Medical College of Jinan University, Zhuhai People's Hospital, The Affiliated Hospital of Beijing Institute of Technology, Zhuhai, China; Institute of interventional and intelligent Medical Engineering, Jinan University, Zhuhai, China.

National Key Laboratory of Veterinary Public Health Security, College of Veterinary Medicine, China Agricultural University, Beijing, China.

出版信息

Trends Mol Med. 2025 Mar 25. doi: 10.1016/j.molmed.2025.03.001.

DOI:10.1016/j.molmed.2025.03.001

PMID:40140306

Abstract

Frequent spillovers and recent geospatial expansion of avian influenza virus (AIV) pose significant economic and public health threats. Recent advances in vaccine technologies, bioinformatics, and artificial intelligence will provide newer approaches to target genetically diverse and rapidly evolving AIVs. Here, we review recent advances in, and perspectives on, developing universal vaccines needed for the effective control of AIVs.

摘要

禽流感病毒（AIV）频繁的溢出以及近期在地理空间上的传播对经济和公共卫生构成了重大威胁。疫苗技术、生物信息学和人工智能方面的最新进展将为针对基因多样且快速进化的AIVs提供更新的方法。在此，我们综述了有效控制AIVs所需的通用疫苗研发的最新进展及前景。