Qian Hao, Lv Jiaqi, Hu Xiuping
Department of Pharmacy, The Affiliated Chuzhou Hospital of Anhui Medical University, 369th Zhuwengxi Road, Nanqiao District, Chuzhou, 239000, China.
Tianjin University of Science and Technology, 1038th Dagu Nan Road, Hexi District, Tianjin, China.
Sci Rep. 2025 Mar 27;15(1):10520. doi: 10.1038/s41598-025-95348-5.
Glioma remains a significant global health challenge, and is characterized by a persistently high mortality rate. Chemotherapy is a common treatment for glioma, but many anticancer drugs exhibit poor permeability across the blood-brain barrier (BBB) and fail to reach tumor tissues adequately, while also exerting toxic effects on normal cells. To address these issues, this study investigated the use of niosomes (Nio), which are biocompatible, biodegradable, and non-immunogenic, to encapsulate curcumin (Cur) and enhance its delivery to glioma tissues. Niosomes were prepared using the non-ionic surfactant sorbitan monostearate (Span 60) and cholesterol as carrier materials, and subsequently modified with transferrin (TF) to facilitate receptor-mediated transport across the BBB. The resulting TF-modified curcumin niosomes (TF-Cur-Nio) demonstrated enhanced targeting of brain tumors, improved anti-glioma efficacy, and favorable in vivo safety. These findings suggest that the TF-Cur-Nio delivery system has significant potential for advancing glioma treatment by overcoming the limitations of conventional chemotherapy and improving drug delivery to the brain.
胶质瘤仍然是一项重大的全球健康挑战，其特点是死亡率持续居高不下。化疗是治疗胶质瘤的常用方法，但许多抗癌药物在血脑屏障（BBB）中的渗透性较差，无法充分到达肿瘤组织，同时还会对正常细胞产生毒性作用。为了解决这些问题，本研究调查了使用具有生物相容性、可生物降解且无免疫原性的脂质体（Nio）来包裹姜黄素（Cur）并增强其向胶质瘤组织的递送。使用非离子表面活性剂单硬脂酸山梨醇酯（Span 60）和胆固醇作为载体材料制备脂质体，随后用转铁蛋白（TF）进行修饰，以促进通过血脑屏障的受体介导转运。所得的转铁蛋白修饰的姜黄素脂质体（TF-Cur-Nio）表现出对脑肿瘤的靶向性增强、抗胶质瘤疗效提高以及良好的体内安全性。这些发现表明，TF-Cur-Nio递送系统通过克服传统化疗的局限性并改善药物向脑部的递送，在推进胶质瘤治疗方面具有巨大潜力。
