Li Xin, Wang Yongfeng, Ren Minmin, Liu Qian, Li Jiajia, Zhang Li, Yao Shun, Tang Lulu, Wen Guorong, An Jiaxing, Jin Hai, Tuo Biguang
Department of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, 149 Dalian Road, Huichuan, Zunyi, 563003, Guizhou, China.
Department of General Surgery, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, 563003, Guizhou Province, China.
Cancer Cell Int. 2025 Mar 26;25(1):118. doi: 10.1186/s12935-025-03737-7.
Tumors are among the most predominant health problems in the world, and the annual incidence of cancer is increasing globally; therefore, there is an urgent need to identify effective therapeutic targets. Chloride intracellular channel 4 (CLIC4) belongs to the family of chloride intracellular channels (CLICs), which are widely expressed in various tissues and organs, such as the brain, lung, pancreas, colorectum, and ovary, and play important roles in promoting apoptosis, promoting angiogenesis, maintaining normal proliferation of endothelial cells, and regulating the assembly and reconstruction of the cytoskeleton. The expression and function of CLIC4 in tumors varies. It has been reported that CLIC4 is low expressed in gastric cancer, skin cancer and prostate cancer, suggesting a tumor suppressor role. Interestingly, CLIC4 is overexpressed in pancreatic, ovarian and breast cancers, indicating a cancer-promoting role. CLIC4 expression is dysregulated in some solid tumors, which may be because CLIC4 is involved in the growth, migration or invasion of some cancer cells through various mechanisms. Regulation of CLIC4 expression may be a potential therapeutic strategy for some tumors. CLIC4 may be a promising therapeutic target and a biomarker for some cancers. In this study, we review the role of CLIC4 in several cancers and its value in the diagnosis and treatment of tumors.
肿瘤是世界上最主要的健康问题之一，全球癌症年发病率正在上升；因此，迫切需要确定有效的治疗靶点。氯离子细胞内通道4（CLIC4）属于氯离子细胞内通道（CLICs）家族，广泛表达于各种组织和器官，如脑、肺、胰腺、结肠和卵巢，在促进细胞凋亡、促进血管生成、维持内皮细胞正常增殖以及调节细胞骨架的组装和重构中发挥重要作用。CLIC4在肿瘤中的表达和功能各不相同。据报道，CLIC4在胃癌、皮肤癌和前列腺癌中低表达，提示其具有肿瘤抑制作用。有趣的是，CLIC4在胰腺癌、卵巢癌和乳腺癌中高表达，表明其具有促癌作用。CLIC4的表达在一些实体瘤中失调，这可能是因为CLIC4通过各种机制参与了某些癌细胞的生长、迁移或侵袭。调节CLIC4的表达可能是某些肿瘤的潜在治疗策略。CLIC4可能是一些癌症有前景的治疗靶点和生物标志物。在本研究中，我们综述了CLIC4在几种癌症中的作用及其在肿瘤诊断和治疗中的价值。
