Karimi-Mostowfi Nicki, Chu Fang-I, Wu Trudy C, Farrell Matthew J, Akingbemi Wisdom, Raldow Ann C
Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
UCLA Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Westwood Radiation Oncology, 200 Medical Plaza, Suite B265, Los Angeles, CA, 90095, USA.
Health Qual Life Outcomes. 2025 Mar 26;23(1):28. doi: 10.1186/s12955-025-02359-x.
To examine racial and ethnic disparities in Health-Related Quality of Life (HRQOL) in older adults with breast cancer, both pre- and post-diagnosis.
Using the SEER-MHOS database, we included patients ≥ 65 years old with breast cancer who completed the Health Outcomes Survey within 24 months pre- and post-diagnosis, and who were non-Hispanic White, non-Hispanic Asian or Pacific Islander, non-Hispanic Black or African American, or Hispanic. HRQOL data was measured via the Physical and Mental Component Summary (PCS, MCS). Univariable and multivariable linear regression models were fitted to assess for potential disparities between races and ethnicities.
On univariable regression models, a numerical drop in mean scores of PCS and MCS was found among all racial/ethnic groups between pre- and post-diagnosis. Among patients in the pre-diagnosis cohort who would be diagnosed with stage IV breast cancer, race was found to be a predictor of PCS with overall significance (p = 0.04). On the local test, compared with Black individuals, White individuals had higher pre-diagnosis PCS scores (+ 13.32, p = 0.03). Race/ethnicity was not found to be a predictor in PCS or MCS scores otherwise.
Among older patients diagnosed with stage IV breast cancer, White individuals had better physical HRQOL than Black patients' pre-diagnosis. The decrease in the numerical HRQOL scores of the physical domain in all groups post-diagnosis highlights the potential negative physical impact of breast cancer has on patients, demonstrating the need for determining the proper resources and support to improve physical HRQOL following diagnosis.
研究老年乳腺癌患者在诊断前后与健康相关的生活质量（HRQOL）方面的种族和民族差异。
使用监测、流行病学和最终结果-医疗保险健康结果调查（SEER-MHOS）数据库，我们纳入了年龄≥65岁的乳腺癌患者，这些患者在诊断前后24个月内完成了健康结果调查，且为非西班牙裔白人、非西班牙裔亚裔或太平洋岛民、非西班牙裔黑人或非裔美国人或西班牙裔。HRQOL数据通过身体和心理成分总结（PCS、MCS）进行测量。采用单变量和多变量线性回归模型来评估种族和民族之间的潜在差异。
在单变量回归模型中，发现所有种族/民族组在诊断前后PCS和MCS的平均得分均有数值下降。在诊断前队列中那些将被诊断为IV期乳腺癌的患者中，种族被发现是PCS的一个具有总体显著性的预测因素（p = 0.04）。在局部检验中，与黑人个体相比，白人个体在诊断前的PCS得分更高（+13.32，p = 0.03）。在其他方面，种族/民族未被发现是PCS或MCS得分的预测因素。
在被诊断为IV期乳腺癌的老年患者中，白人个体在诊断前的身体HRQOL比黑人患者更好。所有组在诊断后身体领域HRQOL得分的数值下降突出了乳腺癌对患者潜在的负面身体影响，表明需要确定适当的资源和支持以改善诊断后的身体HRQOL。
