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KMT2C/D mutations in newly diagnosed acute myeloid leukaemia: Clinical features, genetic co-occurrences and prognostic significance.

作者信息

Wang Wenting, Yang Miao, Zhang Xue, Chen Jiayuan, Qiu Shaowei, Liu Bingcheng, Mi Yingchang, Wang Jianxiang, Wei Hui

机构信息

State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.

Tianjin Institutes of Health Science, Tianjin, China.

出版信息

Clin Transl Med. 2025 Apr;15(4):e70284. doi: 10.1002/ctm2.70284.

DOI:10.1002/ctm2.70284
PMID:40140929
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11946544/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ec/11946544/ad4d07b4869d/CTM2-15-e70284-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ec/11946544/89ad58abaaea/CTM2-15-e70284-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ec/11946544/ad4d07b4869d/CTM2-15-e70284-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ec/11946544/89ad58abaaea/CTM2-15-e70284-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ec/11946544/ad4d07b4869d/CTM2-15-e70284-g001.jpg

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KMT2C/D mutations in newly diagnosed acute myeloid leukaemia: Clinical features, genetic co-occurrences and prognostic significance.新诊断急性髓系白血病中KMT2C/D突变：临床特征、基因共现及预后意义
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本文引用的文献

1
KMT2 Family of H3K4 Methyltransferases: Enzymatic Activity-dependent and -independent Functions.KMT2 家族的 H3K4 甲基转移酶：依赖于酶活性和不依赖于酶活性的功能。
J Mol Biol. 2024 Apr 1;436(7):168453. doi: 10.1016/j.jmb.2024.168453. Epub 2024 Jan 22.
2
Molecular evaluation of gene mutation profiles and copy number variations in pediatric acute myeloid leukemia.儿童急性髓细胞白血病基因突变谱和拷贝数变异的分子评估。
Leuk Res. 2022 Nov;122:106954. doi: 10.1016/j.leukres.2022.106954. Epub 2022 Sep 20.
3
Profiling of somatic mutations in acute myeloid leukemia with FLT3-ITD at diagnosis and relapse.
初诊及复发时伴有FLT3-ITD的急性髓系白血病体细胞突变分析
Blood. 2015 Nov 26;126(22):2491-501. doi: 10.1182/blood-2015-05-646240. Epub 2015 Oct 5.
4
Hijacked in cancer: the KMT2 (MLL) family of methyltransferases.癌症中的“劫持者”：KMT2（MLL）甲基转移酶家族
Nat Rev Cancer. 2015 Jun;15(6):334-46. doi: 10.1038/nrc3929.
5
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.成人新发急性髓系白血病的基因组和表观基因组图谱。
N Engl J Med. 2013 May 30;368(22):2059-74. doi: 10.1056/NEJMoa1301689. Epub 2013 May 1.
6
Commonly altered genomic regions in acute myeloid leukemia are enriched for somatic mutations involved in chromatin remodeling and splicing.在急性髓细胞白血病中常见改变的基因组区域富含涉及染色质重塑和剪接的体细胞突变。
Blood. 2012 Nov 1;120(18):e83-92. doi: 10.1182/blood-2011-12-401471. Epub 2012 Sep 13.
7
A decade of exploring the cancer epigenome - biological and translational implications.一个探索癌症表观基因组的十年 - 生物学和转化意义。
Nat Rev Cancer. 2011 Sep 23;11(10):726-34. doi: 10.1038/nrc3130.
8
MLL2, the second human homolog of the Drosophila trithorax gene, maps to 19q13.1 and is amplified in solid tumor cell lines.MLL2是果蝇三体胸节基因在人类中的第二个同源基因，定位于19q13.1，在实体瘤细胞系中发生扩增。
Oncogene. 1999 Dec 23;18(56):7975-84. doi: 10.1038/sj.onc.1203291.
9
Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias.鉴定出一个基因MLL，它跨越了与人类白血病相关的11q23易位中的断点。
Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10735-9. doi: 10.1073/pnas.88.23.10735.