Parra Meder Álvaro, Costa Rosana, López-Jarana Paula, Ríos-Carrasco Blanca, Relvas Marta, Salazar Filomena
School of Dentistry, Universidad de Sevilla, C/Avicena s/n, 41009 Sevilla, Spain.
Department of Medicine and Oral Surgery, University Institute of Health Sciences (IUCS-CESPU), 4585-116 Gandra, Portugal.
Int J Mol Sci. 2025 Mar 12;26(6):2552. doi: 10.3390/ijms26062552.
There is currently little information on the immune profile of adult type 1 diabetes patients diagnosed with periodontal disease. The aim of this systematic review is to bring together the known evidence of which inflammatory markers, measured in salivary flow or gingival crevicular fluid and serum blood, are present in both pathologies. Following the Preferred Reporting Items for Systematic reviews and Meta-Analys guidelines, we systematically searched in the PubMed, Web of Science, Scopus and Cochrane Library databases for studies on the associations of different chemokines with type 1 diabetes mellitus and periodontal disease. From a total of 703 patients, of which 526 were patients diagnosed with type 1 diabetes and 215 were controls without diabetes, multiple inflammatory mediators, such as interleukin 8, which showed higher concentrations in the crevicular fluid in several studies of type 1 diabetes patients and a greater severity in its effects on the periodontal status, as well as osteoprotegerin and tumor necrosis factor alpha, have been found elevated in diabetic patients with poor periodontal control. The results suggest that interleukin 8, tumor necrosis factor alpha and osteoprotegerin may be promising novel biomarkers of type 1 diabetes mellitus, and may also indicate the susceptibility profile in these individuals for the worsening of the patient's periodontal status.
目前，关于被诊断患有牙周病的成年1型糖尿病患者的免疫特征的信息很少。本系统评价的目的是汇总已知证据，以确定在唾液流量、龈沟液和血清中测量的哪些炎症标志物在这两种疾病中均存在。按照系统评价和Meta分析的首选报告项目指南，我们在PubMed、科学网、Scopus和Cochrane图书馆数据库中系统检索了关于不同趋化因子与1型糖尿病和牙周病关联的研究。在总共703名患者中，其中526名是被诊断患有1型糖尿病的患者，215名是无糖尿病的对照，在牙周控制不佳的糖尿病患者中发现多种炎症介质升高，如白细胞介素8（在几项1型糖尿病患者研究中其在龈沟液中的浓度较高，且对牙周状况的影响更严重）以及骨保护素和肿瘤坏死因子α。结果表明，白细胞介素8、肿瘤坏死因子α和骨保护素可能是1型糖尿病有前景的新型生物标志物，也可能表明这些个体中患者牙周状况恶化的易感性特征。
