胰岛素抵抗的进展——分子机制、治疗靶点及未来方向
Advances in Insulin Resistance-Molecular Mechanisms, Therapeutic Targets, and Future Directions.
作者信息
Ahn Byungyong
机构信息
Department of Food Science and Nutrition, University of Ulsan, Ulsan 44610, Republic of Korea.
Basic-Clinical Convergence Research Institute, University of Ulsan, Ulsan 44610, Republic of Korea.
出版信息
Int J Mol Sci. 2025 Mar 13;26(6):2574. doi: 10.3390/ijms26062574.
Abstract
The development of insulin resistance (IR) is characterized by a series of metabolic disturbances, including, but not limited to, impaired glucose uptake, increased blood sugar levels, and disrupted lipid metabolism [...].
摘要
胰岛素抵抗（IR）的发展特点是一系列代谢紊乱，包括但不限于葡萄糖摄取受损、血糖水平升高和脂质代谢紊乱[...]。
相似文献
1
Advances in Insulin Resistance-Molecular Mechanisms, Therapeutic Targets, and Future Directions.胰岛素抵抗的进展——分子机制、治疗靶点及未来方向
Int J Mol Sci. 2025 Mar 13;26(6):2574. doi: 10.3390/ijms26062574.
2
Metabolism and insulin signaling in common metabolic disorders and inherited insulin resistance.常见代谢紊乱和遗传性胰岛素抵抗中的代谢与胰岛素信号传导
Dan Med J. 2014 Jul;61(7):B4890.
3
Sexual dimorphism in the molecular mechanisms of insulin resistance during a critical developmental window in Wistar rats.胰岛素抵抗在关键发育期的 Wistar 大鼠分子机制中的性别二态性。
Cell Commun Signal. 2022 Oct 12;20(1):154. doi: 10.1186/s12964-022-00965-6.
4
Prospective evaluation of insulin resistance and lipid metabolism in women receiving oral contraceptives.口服避孕药女性胰岛素抵抗和脂质代谢的前瞻性评估
Clin Endocrinol (Oxf). 1994 Feb;40(2):249-55. doi: 10.1111/j.1365-2265.1994.tb02476.x.
5
Continuous Exposure of Nonobese Adult Male Rats to a Soft-Textured, Readily Absorbable Diet Induces Insulin Resistance and Derangements in Hepatic Glucose and Lipid Metabolism.非肥胖成年雄性大鼠持续食用质地柔软、易于吸收的饮食会导致胰岛素抵抗以及肝脏葡萄糖和脂质代谢紊乱。
J Nutr. 2025 May;155(5):1387-1397. doi: 10.1016/j.tjnut.2025.03.009. Epub 2025 Mar 10.
6
Advances and challenges in measuring hepatic glucose uptake with FDG PET: implications for diabetes research.使用 FDG PET 测量肝葡萄糖摄取的进展与挑战：对糖尿病研究的影响。
Diabetologia. 2024 Mar;67(3):407-419. doi: 10.1007/s00125-023-06055-7. Epub 2023 Dec 15.
7
Tangduqing Granules Attenuate Insulin Resistance and Abnormal Lipid Metabolism through the Coordinated Regulation of PPAR and DGAT2 in Type 2 Diabetic Rats.糖度清颗粒通过协调调控 2 型糖尿病大鼠的 PPAR 和 DGAT2 减轻胰岛素抵抗和异常脂质代谢。
J Diabetes Res. 2019 Mar 25;2019:7403978. doi: 10.1155/2019/7403978. eCollection 2019.
8
Exploring the role of Myo-inositol in alleviating insulin resistance in polycystic ovary syndrome through the AMPK/GLUT4 pathway.通过AMPK/GLUT4途径探索肌醇在改善多囊卵巢综合征胰岛素抵抗中的作用。
Mol Biol Rep. 2025 May 13;52(1):454. doi: 10.1007/s11033-025-10553-9.
9
Comparison of glucose and lipid metabolism and bone mineralization in patients with growth hormone deficiency with and without long-term growth hormone replacement.生长激素缺乏症患者长期生长激素替代治疗与未治疗患者的糖脂代谢及骨矿化比较。
Metabolism. 2010 Mar;59(3):350-8. doi: 10.1016/j.metabol.2009.08.002. Epub 2009 Oct 2.
10
Effect of short-term low-intensity exercise on insulin sensitivity, insulin secretion, and glucose and lipid metabolism in non-obese Japanese type 2 diabetic patients.短期低强度运动对非肥胖日本2型糖尿病患者胰岛素敏感性、胰岛素分泌及糖脂代谢的影响
Horm Metab Res. 2002 Jan;34(1):27-31. doi: 10.1055/s-2002-19963.
引用本文的文献
1
The Role of S6K1 in Aging and Alzheimer's Disease: Mechanistic Insights and Therapeutic Potential.S6K1在衰老和阿尔茨海默病中的作用：机制洞察与治疗潜力
Int J Mol Sci. 2025 Jun 20;26(13):5923. doi: 10.3390/ijms26135923.
2
Correction: Ahn, B. Advances in Insulin Resistance-Molecular Mechanisms, Therapeutic Targets, and Future Directions. 2025, , 2574.更正：安，B.《胰岛素抵抗的进展——分子机制、治疗靶点及未来方向》。2025年，，2574。
Int J Mol Sci. 2025 Apr 28;26(9):4171. doi: 10.3390/ijms26094171.
本文引用的文献
1
Type 2 Diabetes Mellitus Exacerbates Pathological Processes of Parkinson's Disease: Insights from Signaling Pathways Mediated by Insulin Receptors.2型糖尿病加剧帕金森病的病理过程：胰岛素受体介导的信号通路的见解
Neurosci Bull. 2025 Apr;41(4):676-690. doi: 10.1007/s12264-024-01342-8. Epub 2025 Jan 4.
2
A Nonlinear Relation between Body Mass Index and Long-Term Poststroke Functional Outcome-The Importance of Insulin Resistance, Inflammation, and Insulin-like Growth Factor-Binding Protein-1.体质指数与长期卒中后功能结局之间的非线性关系——胰岛素抵抗、炎症和胰岛素样生长因子结合蛋白-1的重要性。
Int J Mol Sci. 2024 Apr 30;25(9):4931. doi: 10.3390/ijms25094931.
3
The Contribution of Type 2 Diabetes to Parkinson's Disease Aetiology.2型糖尿病对帕金森病病因的影响。
Int J Mol Sci. 2024 Apr 15;25(8):4358. doi: 10.3390/ijms25084358.
4
The potential of therapeutic strategies targeting mitochondrial biogenesis for the treatment of insulin resistance and type 2 diabetes mellitus.靶向线粒体生物发生的治疗策略治疗胰岛素抵抗和 2 型糖尿病的潜力。
Arch Pharm Res. 2024 Mar;47(3):219-248. doi: 10.1007/s12272-024-01490-5. Epub 2024 Mar 14.
5
Ketosis Suppression and Ageing (KetoSAge): The Effects of Suppressing Ketosis in Long Term Keto-Adapted Non-Athletic Females.酮症抑制与衰老（KetoSAge）：长期生酮适应的非运动女性抑制酮症的影响。
Int J Mol Sci. 2023 Oct 26;24(21):15621. doi: 10.3390/ijms242115621.
6
Glucagon and Its Receptors in the Mammalian Heart.哺乳动物心脏中的胰高血糖素及其受体。
Int J Mol Sci. 2023 Aug 15;24(16):12829. doi: 10.3390/ijms241612829.
7
The Role of Macrophage Populations in Skeletal Muscle Insulin Sensitivity: Current Understanding and Implications.巨噬细胞群体在骨骼肌胰岛素敏感性中的作用：当前的认识和影响。
Int J Mol Sci. 2023 Jul 14;24(14):11467. doi: 10.3390/ijms241411467.
8
The Function of MondoA and ChREBP Nutrient-Sensing Factors in Metabolic Disease.MondoA 和 ChREBP 营养感应因子在代谢性疾病中的功能。
Int J Mol Sci. 2023 May 16;24(10):8811. doi: 10.3390/ijms24108811.
9
The crucial role and mechanism of insulin resistance in metabolic disease.胰岛素抵抗在代谢性疾病中的关键作用及其机制。
Front Endocrinol (Lausanne). 2023 Mar 28;14:1149239. doi: 10.3389/fendo.2023.1149239. eCollection 2023.
10
The Attenuation of Insulin/IGF-1 Signaling Pathway Plays a Crucial Role in the Myo-Inositol-Alleviated Aging in .胰岛素/IGF-1 信号通路的衰减在肌醇缓解衰老中起着关键作用。
Int J Mol Sci. 2023 Mar 24;24(7):6194. doi: 10.3390/ijms24076194.
Zotero 插件