Department of Food Science and Nutrition, Pukyong National University, Busan 48513, Republic of Korea.
Department of Smart Green Technology Engineering, Pukyong National University, Busan 48513, Republic of Korea.
Int J Mol Sci. 2023 Jul 14;24(14):11467. doi: 10.3390/ijms241411467.
Insulin resistance is a crucial factor in the development of type 2 diabetes mellitus (T2DM) and other metabolic disorders. Skeletal muscle, the body's largest insulin-responsive tissue, plays a significant role in the pathogenesis of T2DM due to defects in insulin signaling. Recently, there has been growing evidence that macrophages, immune cells essential for tissue homeostasis and injury response, also contribute to the development of skeletal muscle insulin resistance. This review aims to summarize the current understanding of the role of macrophages in skeletal muscle insulin resistance. Firstly, it provides an overview of the different macrophage populations present in skeletal muscle and their specific functions in the development of insulin resistance. Secondly, it examines the underlying mechanisms by which macrophages promote or alleviate insulin resistance in skeletal muscle, including inflammation, oxidative stress, and altered metabolism. Lastly, the review discusses potential therapeutic strategies targeting macrophages to improve skeletal muscle insulin sensitivity and metabolic health.
胰岛素抵抗是 2 型糖尿病（T2DM）和其他代谢紊乱发展的关键因素。骨骼肌是人体对胰岛素反应最敏感的组织，由于胰岛素信号缺陷，在 T2DM 的发病机制中起着重要作用。最近越来越多的证据表明，巨噬细胞作为组织稳态和损伤反应所必需的免疫细胞，也有助于骨骼肌胰岛素抵抗的发展。本综述旨在总结巨噬细胞在骨骼肌胰岛素抵抗中的作用的现有认识。首先，它概述了存在于骨骼肌中的不同巨噬细胞群体及其在胰岛素抵抗发展中的特定功能。其次，它研究了巨噬细胞促进或缓解骨骼肌胰岛素抵抗的潜在机制，包括炎症、氧化应激和代谢改变。最后，该综述讨论了针对巨噬细胞的潜在治疗策略，以改善骨骼肌胰岛素敏感性和代谢健康。
