Zhang Jingjie, Wang Xueli, Fang Juan, Li Yingying, Yu Yonghui, Wang Jing, Sun Baoguo
Key Laboratory of Geriatric Nutrition and Health, Ministry of Education, Beijing Technology and Business University, Beijing 100048, China.
China-Canada Joint Laboratory of Food Nutrition and Health, Beijing Technology and Business University, Beijing 100048, China.
Int J Mol Sci. 2025 Mar 16;26(6):2674. doi: 10.3390/ijms26062674.
Rheumatoid arthritis (RA) is a systemic autoimmune disease that commonly causes pain in joints and the progressive destruction of cartilage and bone, which significantly reduces the quality of life and increases the social burden. However, there is still no cure for RA, so it is highly important to explore additional adjuvant treatment methods. Studies have indicated that malnutrition, changes in intestinal microbiota, and changes in immune status caused by dietary imbalance are directly related to the onset of RA, indicating that dietary intervention may offer a simple, economical, and practical avenue to relieve RA. Therefore, in this review, we discuss the pathogenesis of RA and summarize the influence of different dietary patterns on RA. In particular, we pointed out that high-fat, high-sugar, and high-salt diets contribute to RA progression, whereas the Mediterranean diet (MD) is beneficial for preventing RA. Furthermore, the ingredients of food, such as dietary fiber, probiotics, and vitamins, help reduce the level of inflammation and relieve joint pain, which may play critical roles in the treatment of RA. Therefore, dietary intervention provides a potential effective approach for adjuvant therapy of RA.
类风湿关节炎（RA）是一种全身性自身免疫性疾病，通常会导致关节疼痛以及软骨和骨骼的渐进性破坏，这会显著降低生活质量并增加社会负担。然而，RA 仍然无法治愈，因此探索额外的辅助治疗方法非常重要。研究表明，营养不良、肠道微生物群的变化以及饮食不均衡引起的免疫状态变化与 RA 的发病直接相关，这表明饮食干预可能为缓解 RA 提供一种简单、经济且实用的途径。因此，在本综述中，我们讨论了 RA 的发病机制，并总结了不同饮食模式对 RA 的影响。特别是，我们指出高脂肪、高糖和高盐饮食会促进 RA 的进展，而地中海饮食（MD）则有利于预防 RA。此外，食物成分，如膳食纤维、益生菌和维生素，有助于降低炎症水平并缓解关节疼痛，这可能在 RA 的治疗中发挥关键作用。因此，饮食干预为 RA 的辅助治疗提供了一种潜在的有效方法。
