Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland.
Department of Medical Biology, Medical University of Warsaw, 00-575 Warsaw, Poland.
Nutrients. 2024 Sep 23;16(18):3215. doi: 10.3390/nu16183215.
Rheumatoid arthritis (RA) is a chronic and progressive autoimmune disease. The pathogenesis of RA is complex and involves interactions between articular cells, such as fibroblast-like synoviocytes, and immune cells. These cells secrete pro-inflammatory cytokines, chemokines, metalloproteinases and other molecules that together participate in joint degradation. The current evidence suggests the important immunoregulatory role of the gut microbiome, which can affect susceptibility to diseases and infections. An altered microbiome, a phenomenon known as gut dysbiosis, is associated with the development of inflammatory diseases. Importantly, the profile of the gut microbiome depends on dietary habits. Therefore, dietary elements and interventions can indirectly impact the progression of diseases. This review summarises the evidence on the involvement of gut dysbiosis and diet in the pathogenesis of RA.
类风湿关节炎（RA）是一种慢性、进行性自身免疫性疾病。RA 的发病机制复杂，涉及关节细胞（如成纤维样滑膜细胞）与免疫细胞之间的相互作用。这些细胞分泌促炎细胞因子、趋化因子、金属蛋白酶和其他分子，共同参与关节降解。目前的证据表明，肠道微生物组具有重要的免疫调节作用，可影响疾病和感染的易感性。微生物组的改变，即所谓的肠道菌群失调，与炎症性疾病的发展有关。重要的是，肠道微生物组的特征取决于饮食习惯。因此，饮食因素和干预措施可以间接影响疾病的进展。这篇综述总结了肠道菌群失调和饮食在 RA 发病机制中的作用的证据。
