膜联蛋白A2蛋白及其在神经退行性变过程中的作用。

ANXA2 Protein and Its Role in Neurodegeneration Processes.

作者信息

Partevian Suzanna A, Slominsky Petr A, Shadrina Maria I, Alieva Anelya Kh

机构信息

National Research Centre "Kurchatov Institute", 2 Kurchatova Sq., 123182 Moscow, Russia.

出版信息

Life (Basel). 2025 Mar 4;15(3):402. doi: 10.3390/life15030402.

DOI:10.3390/life15030402

PMID:40141747

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11943692/

Abstract

ANXA2 is a multifunctional member of the annexin protein family, implicated in vesicular transport, antioxidant defense, and actin remodeling. Its role in oncogenesis is actively investigated, notably in glioblastoma, astrocytoma, and breast cancer. However, a growing body of literature explores ANXA2's involvement in neurodegenerative processes. The evidence suggests a potential contribution of ANXA2 to the pathogenesis of primary and secondary tauopathies, as well as Parkinson's disease. It is crucial to note that the majority of these findings are correlative and necessitate further experimental validation. This review therefore presents a comprehensive analysis of data pertaining to ANXA2's involvement in various cellular processes, the disruption of which contributes to neurological pathologies.

摘要

膜联蛋白A2（ANXA2）是膜联蛋白家族的一个多功能成员，参与囊泡运输、抗氧化防御和肌动蛋白重塑。目前正在积极研究其在肿瘤发生中的作用，尤其是在胶质母细胞瘤、星形细胞瘤和乳腺癌中。然而，越来越多的文献探讨了ANXA2在神经退行性过程中的参与情况。有证据表明，ANXA2可能在原发性和继发性tau蛋白病以及帕金森病的发病机制中发挥作用。需要注意的是，这些发现大多是相关性的，需要进一步的实验验证。因此，本综述对与ANXA2参与各种细胞过程相关的数据进行了全面分析，这些细胞过程的破坏会导致神经病理学。