Wang Aijia, Zhang Hong, Li Xing, Zhao Yin
Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
Neural Regen Res. 2024 Mar;19(3):591-597. doi: 10.4103/1673-5374.380882.
The therapeutic potential of Annexin A1, an important member of the Annexin superfamily, has become evident in results of experiments with multiple human systems and animal models. The anti-inflammatory and pro-resolving effects of Annexin A1 are characteristic of pathologies involving the nervous system. In this review, we initially describe the expression sites of Annexin A1, then outline the mechanisms by which Annexin A1 maintains the neurological homeostasis through either formyl peptide receptor 2 or other molecular approaches; and, finally, we discuss the neuroregenerative potential qualities of Annexin A1. The eye and the nervous system are anatomically and functionally connected, but the association between visual system pathogenesis, especially in the retina, and Annexin A1 alterations has not been well summarized. Therefore, we explain the beneficial effects of Annexin A1 for ocular diseases, especially for retinal diseases and glaucoma on the basis of published findings, and we explore present and future delivery strategies for Annexin A1 to the retina.
膜联蛋白A1是膜联蛋白超家族的重要成员，在多种人体系统和动物模型的实验结果中，其治疗潜力已变得明显。膜联蛋白A1的抗炎和促消退作用是涉及神经系统的病理学特征。在本综述中，我们首先描述膜联蛋白A1的表达位点，然后概述膜联蛋白A1通过甲酰肽受体2或其他分子途径维持神经稳态的机制；最后，我们讨论膜联蛋白A1的神经再生潜在特性。眼睛和神经系统在解剖学和功能上相互关联，但视觉系统发病机制，尤其是视网膜发病机制与膜联蛋白A1改变之间的关联尚未得到很好的总结。因此，我们根据已发表的研究结果解释膜联蛋白A1对眼部疾病，特别是对视网膜疾病和青光眼的有益作用，并探讨目前和未来将膜联蛋白A1递送至视网膜的策略。
