Yildirim Ufuk, Taskin Gulten, Baser Meliyke Hatun, Tugmen Burak, Yaliniz Busranur, Camlidag Ilkay, Meric Murat
Department of Cardiology, Faculty of Medicine, Ondokuz Mayis University, 55200 Samsun, Turkey.
Department of Radiology, Faculty of Medicine, Ondokuz Mayis University, 55200 Samsun, Turkey.
Medicina (Kaunas). 2025 Feb 22;61(3):381. doi: 10.3390/medicina61030381.
: Recent studies have demonstrated that pulmonary arterial hypertension (PAH) is a vascular disease that extends beyond the pulmonary vasculature. PAH has been associated with increased intramural coronary arteriolar medial thickness and decreased coronary arteriolar luminal area in both human and experimental models of the disease. The objective of this study was to assess the luminal diameter of epicardial coronary arteries in patients with PAH. : Fifty patients with PAH who underwent cardiac computed tomography (CT) angiography at our center were included in this retrospective study. Fifty patients without pulmonary hypertension matched for age, sex, and coronary dominance were also included. Coronary artery luminal diameters measured by cardiac CT angiography were compared between the groups, in addition to baseline characteristics and standard cardiac measurements. Correlation analysis was also performed. : The diameters of the left main coronary artery, left anterior descending artery, and left circumflex artery were comparable between the groups. However, the right coronary artery (RCA) diameter was found to be greater in the PAH group (3.51 ± 0.66 mm vs. 3.02 ± 0.49 mm, < 0.001). The RCA diameter exhibited a positive moderate correlation with the main pulmonary artery diameter (R = 0.517, < 0.001), right atrial area (R = 0.515, < 0.001), and right ventricular diastolic diameter (R = 0.506, < 0.001). : PAH may be associated with an increase in the RCA diameter.
近期研究表明，肺动脉高压（PAH）是一种超出肺血管系统范围的血管疾病。在该疾病的人类和实验模型中，PAH都与壁内冠状动脉小动脉中层厚度增加及冠状动脉小动脉管腔面积减小有关。本研究的目的是评估PAH患者的心外膜冠状动脉管腔直径。
本回顾性研究纳入了在我们中心接受心脏计算机断层扫描（CT）血管造影的50例PAH患者。还纳入了50例年龄、性别和冠状动脉优势匹配的无肺动脉高压患者。除了基线特征和标准心脏测量外，还比较了两组通过心脏CT血管造影测量的冠状动脉管腔直径。还进行了相关性分析。
两组之间左冠状动脉主干、左前降支和左旋支的直径相当。然而，发现PAH组的右冠状动脉（RCA）直径更大（3.51±0.66毫米对3.02±0.49毫米，<0.001）。RCA直径与主肺动脉直径（R = 0.517，<0.001）、右心房面积（R = 0.515，<0.001）和右心室舒张直径（R = 0.506，<0.001）呈中度正相关。
PAH可能与RCA直径增加有关。
