Kim Sang Hun, Yoon Sang Min, Ahn Ji Hye, Choi Yoon Ji
Department of Anesthesiology and Pain Medicine, College of Medicine, Chosun University, Gwangju 61453, Republic of Korea.
Department of Anesthesiology and Pain Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Ansan 15355, Republic of Korea.
Medicina (Kaunas). 2025 Mar 17;61(3):523. doi: 10.3390/medicina61030523.
Patients with type 2 diabetes are at a higher risk of postoperative complications, such as infections, delayed wound healing, and increased mortality compared to non-diabetic patients. This prospective randomized study aims to compare the effects of two anesthetics, remimazolam and propofol, on blood glucose levels and immune function in diabetic patients undergoing surgery. Seventy-four diabetic patients undergoing general anesthesia were randomly assigned to receive either remimazolam or propofol. Plasma blood glucose levels, anti-inflammatory markers, and insulin levels were measured during the perioperative period. No statistically significant differences were observed between the remimazolam and propofol groups in terms of neutrophil-to-lymphocyte ratio, anti-inflammatory markers, or glucose levels during the perioperative period ( value > 0.05). These results suggest that there is no difference between propofol and remimazolam in immune function deterioration that occurs due to surgical stress. This study is limited by its small sample size, and in future, larger trials could be conducted to find differences in the effects of blood sugar levels and serum inflammatory markers between the two groups.
与非糖尿病患者相比，2型糖尿病患者术后发生并发症的风险更高，如感染、伤口愈合延迟和死亡率增加。这项前瞻性随机研究旨在比较两种麻醉剂瑞米唑仑和丙泊酚对接受手术的糖尿病患者血糖水平和免疫功能的影响。74例接受全身麻醉的糖尿病患者被随机分配接受瑞米唑仑或丙泊酚。在围手术期测量血浆血糖水平、抗炎标志物和胰岛素水平。在围手术期，瑞米唑仑组和丙泊酚组在中性粒细胞与淋巴细胞比率、抗炎标志物或血糖水平方面未观察到统计学上的显著差异（P值>0.05）。这些结果表明，丙泊酚和瑞米唑仑在因手术应激导致的免疫功能恶化方面没有差异。本研究受样本量小的限制，未来可进行更大规模的试验，以发现两组在血糖水平和血清炎症标志物影响方面的差异。
