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肝硬化患者的连续无创血流动力学监测——是福是祸?

Continuous Non-Invasive Hemodynamic Monitoring in Cirrhotic Patients-Friend or Foe?

作者信息

Crihan Mirela, Alexa Alexandru Leonard, Valean Dan, Ionescu Daniela

机构信息

1st Department of Anesthesia and Intensive Care, "Iuliu Haţieganu" University of Medicine and Pharmacy, 400347 Cluj-Napoca, Romania.

Research Association in Anesthesia and Intensive Care (ACATI), 400394 Cluj-Napoca, Romania.

出版信息

Medicina (Kaunas). 2025 Mar 19;61(3):536. doi: 10.3390/medicina61030536.

Abstract

: Liver cirrhosis leads to significant hemodynamic changes, particularly portal hypertension and a hyperdynamic circulatory state. Traditional invasive methods for hemodynamic monitoring, while accurate, carry risks such as infection and hemorrhage in a patient predisposed to these conditions. This study evaluates the accuracy of non-invasive continuous hemodynamic monitoring compared to a minimally invasive method in patients with decompensated liver cirrhosis. : The study enrolled 51 patients with decompensated liver cirrhosis requiring continuous hemodynamic monitoring in the ICU. Patients underwent simultaneous monitoring via the minimally invasive FloTrac system and continuous non-invasive ClearSight sensor over 24 h, with measurements registered at 6 h intervals. Hemodynamic parameters measured included cardiac output (CO), cardiac index (CI), stroke volume (SV), stroke volume variation (SVV), systemic vascular resistance (SVR), and mean arterial pressure (MAP). : Significant discrepancies were observed between the two monitoring methods for most parameters, particularly CO, CI, and MAP, at most time intervals. However, SVV measurements showed no significant differences, indicating similar efficacy in assessing fluid responsiveness between the devices. : The ClearSight system, although a valuable non-invasive alternative, demonstrated lower accuracy compared to the FloTrac system for hemodynamic measurements in patients with decompensated liver cirrhosis. Its effectiveness in assessing fluid responsiveness, particularly by SVV, suggests it could play a role in the monitoring of these patients, especially when invasive techniques have increased risks.

摘要

肝硬化会导致显著的血流动力学变化,尤其是门静脉高压和高动力循环状态。传统的有创血流动力学监测方法虽然准确,但对于易出现这些情况的患者存在感染和出血等风险。本研究评估了在失代偿期肝硬化患者中,与微创方法相比,无创连续血流动力学监测的准确性。

该研究纳入了51例在重症监护病房(ICU)需要进行连续血流动力学监测的失代偿期肝硬化患者。患者通过微创FloTrac系统和无创连续ClearSight传感器同时进行24小时监测,每6小时记录一次测量值。测量的血流动力学参数包括心输出量(CO)、心脏指数(CI)、每搏输出量(SV)、每搏输出量变异度(SVV)、全身血管阻力(SVR)和平均动脉压(MAP)。

在大多数时间间隔内,两种监测方法对大多数参数,尤其是CO、CI和MAP,观察到显著差异。然而,SVV测量值没有显著差异,表明在评估设备之间的液体反应性方面具有相似的效果。

ClearSight系统虽然是一种有价值的无创替代方法,但在失代偿期肝硬化患者的血流动力学测量中,与FloTrac系统相比准确性较低。其在评估液体反应性方面的有效性,尤其是通过SVV评估,表明它可以在这些患者的监测中发挥作用,特别是在有创技术风险增加时。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/472c/11943466/b0f6d1135d82/medicina-61-00536-g001.jpg

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