Leonildi Alessandro, Rosellini Alfredo, Gemignani Giulia, Tiseo Giusy, Falcone Marco, Giordano Cesira, Barnini Simona
Microbiology Unit, Azienda Ospedaliero-Universitaria Pisana, 56126 Pisa, Italy.
Organization of Hospital Services Unit, Azienda Ospedaliero-Universitaria Pisana, 56126 Pisa, Italy.
Microorganisms. 2025 Feb 22;13(3):493. doi: 10.3390/microorganisms13030493.
is one of the most successful and feared nosocomial pathogens. is considered a global threat in the healthcare setting, mainly owing to its ability to acquire multidrug resistance phenotypes. The pathogenesis is guided by its environmental persistence, as well as the production of numerous virulence factors. In several bacteria, the production of pigments, such as melanin, has indeed been linked with virulence and pathogenicity. Melanin is a brownish pigment, rarely observed in , that potentially reduces the susceptibility of the bacteria to host defense mechanisms and environmental insults. This study reports the first outbreak in Europe by pyomelanin-producing strains, in a tertiary-care university hospital in Pisa, Italy. Phenotypic and molecular analyses were performed.
是最成功且令人恐惧的医院病原体之一。在医疗环境中被视为全球威胁，主要因其获得多药耐药表型的能力。其发病机制受其在环境中的持久性以及众多毒力因子的产生所引导。在几种细菌中，色素如黑色素的产生确实与毒力和致病性有关。黑色素是一种棕色色素，在中很少观察到，它可能会降低细菌对宿主防御机制和环境损伤的敏感性。本研究报告了在意大利比萨的一家三级护理大学医院中，首次由产脓性黑色素的菌株引发的欧洲疫情。进行了表型和分子分析。
